6314-98-3

Usage

Uses

Used in Perfume and Flavor Industry:
1-(diethoxymethyl)-2-methoxybenzene is used as a fragrance ingredient for its sweet, floral odor, contributing to the production of perfumes and flavors.
Used in Consumer Products:
1-(diethoxymethyl)-2-methoxybenzene is used as a fragrance ingredient in various consumer products, enhancing their scent and appeal to consumers.
It is important to handle and store 1-(diethoxymethyl)-2-methoxybenzene carefully due to its flammability and potential health hazards.

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 135-02-4 ortho-anisaldehyde 
• 64-17-5 ethanol 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 92397-07-4 α,α-bis(7-hydroxy-5-isopropyltropon-2-yl)-2-methoxytoluene 
• 143445-50-5 2-[(E)-2-(2-Methoxy-phenyl)-vinyl]-1,3,3-trimethyl-3H-indolium; iodide 
• 86657-75-2 1-Methoxy-2-(1,3,3-triethoxy-propyl)-benzene 
• 56707-17-6 2-methoxy-5-chlorosulphonylbenzaldehyde 
• 135-02-4 ortho-anisaldehyde 
• 7335-26-4 ethyl 2-methoxybenzoate 
• 928838-73-7 1-(ethoxy(2-methoxyphenyl)methyl)-1H-imidazole 
• 1338070-65-7 4-(chlorophenylmethylene)-9-(2-methoxy-phenyl)-2-(toluene-4-sulfonyl)-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine 

Relevant academic research and scientific papers

From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: A rational approach towards improved cleavable linkers for biospecific endosomal release

pH-Sensitive linkers designed to undergo selective hydrolysis at acidic pH compared to physiological pH can be used for the selective release of therapeutics at their site of action. In this paper, the hydrolytic cleavage of a wide variety of molecular structures that have been reported for their use in pH-sensitive delivery systems was examined. A wide variety of hydrolytic stability profiles were found among the panel of tested chemical functionalities. Even within a structural family, a slight modification of the substitution pattern has an unsuspected outcome on the hydrolysis stability. This work led us to establish a first classification of these groups based on their reactivities at pH 5.5 and their relative hydrolysis at pH 5.5 vs. pH 7.4. From this classification, four representative chemical functions were selected and studied in-vitro. The results revealed that only the most reactive functions underwent significant lysosomal cleavage, according to flow cytometry measurements. These last results question the acid-based mechanism of action of known drug release systems and advocate for the importance of an in-depth structure-reactivity study, using a tailored methodology, for the rational design and development of bio-responsive linkers.

Direct conversion of acetals to esters with high regioselectivity via O,P-acetals

A new direct conversion of O,O-acetals to esters via O,P-acetal intermediates was developed. The regioselective cleavage of unsymmetrical cyclic acetals occurred to give the more crowded esters as single isomers.

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P1 motif were designed based on initial lead structures 1 and aliskiren (2). (P3-P1)-Benzamide derivatives such as 9a and 34, as well as the corresponding P1 basic tertiary amine derivatives 10 and 35 were found to display low nanomolar inhibition against human renin in vitro.

The thermally induced synthesis of N-(diethoxyphosphoryl)aldimines

The reaction of diethyl phosphoroamidate (2) with aromatic aldehyde diethyl acetals (1) carried out at 120-160°C provides a simple, one-step preparation of N-(diethoxyphosphoryl)aldimines (3a-b). The extension of this reaction to aliphatic aldehyde diethyl acetals failed to give the expected imines.

Preparation of ascorbic acid intermediates

A synthetic route to ascorbic acid is provided in which a 3,5:4,6-protected derivative of gulonic acid is prepared from gulono-1,4-lactone. Oxidation of the derivative and hydrolysis of the resulting product affords 2-ketogulonic acid or ester thereof which can be readily converted to ascorbic acid by known methods.