63141-03-7

Usage

Uses

Used in Food Industry:
2(3H)-Furanone, 3-acetyl-3-fluorodihydro(9CI) is used as a flavoring ingredient for its ability to impart a fruity and caramel-like aroma to bakery goods, beverages, and other food products, enhancing their overall taste and consumer appeal.
Used in Fragrance Industry:
In the fragrance industry, 2(3H)-Furanone, 3-acetyl-3-fluorodihydro(9CI) is utilized as a fragrance ingredient, capitalizing on its pleasant and complex scent to create captivating perfumes and other scented products.
Used in Research and Development:
2(3H)-Furanone, 3-acetyl-3-fluorodihydro(9CI) is also used in research settings to explore its potential biological activities, such as antimicrobial and antioxidant properties, which could lead to new applications in pharmaceuticals or other industries.

Upstream product

• 2986-00-7 3-acetyl-3-chlorodihydrofuran-2(3H)-one 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 

Downstream Products

• 63141-10-6 1-(1-fluorocyclopropyl)ethanone 
• 63141-04-8 3-fluoro-5-bromo-2-pentanone 

Relevant academic research and scientific papers

Apparent electrophilic fluorination of 1,3-dicarbonyl compounds using nucleophilic fluoride mediated by PhI(OAc)2

The apparent electrophilic fluorination of 1,3-dicarbonyl compounds using Et3N·3HF as a nucleophilic fluoride source is reported. This reaction requires PhI(OAc)2 as oxidant and can be conducted safely in standard laboratory glassware. Alternative selectivity compared to Selectfluor was observed in some cases. This approach may reduce our reliance on difficult-to-handle fluorine gas and expensive electrophilic fluorinating agents derived from elemental fluorine. Mechanistic analysis related to the active fluorinating species and fluoride/acetate exchange is presented. The apparent electrophilic fluorination of 1,3-dicarbonyl compounds using Et3N·3HF mediated by the in-situ formation of PhIF2 from PhI(OAc)2 is reported. This can be performed safely in standard laboratory glassware, and this approach may reduce our reliance on difficult-to-handle fluorine gas and expensive electrophilic fluorinating agents derived from elemental fluorine.

Direct fluorination of 1,3-dicarbonyl compounds

In acid media, 1,3-diketones and 1,3-keloesters can be fluorinated in high yield and often with high conversion mainly to the corresponding 2-fluoro- compounds. Diesters such as diethyl malonate do not react with fluorine under the same reaction conditions. The mechanism of these reactions has been investigated and while the identity of the electrophilic fluorinating species is uncertain, we believe that the essential features of the reaction pathway are understood. Copyright