6315-90-8

Usage

Uses

Used in Pharmaceutical Synthesis:
4,5-METHYLENEDIOXY-2-NITROCINNAMIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows for the creation of new molecules with potential therapeutic effects.
Used in Medicinal Chemistry Research:
4,5-METHYLENEDIOXY-2-NITROCINNAMIC ACID is used as a research compound for exploring its potential anti-inflammatory and anticonvulsant properties. Its ability to modulate biological pathways and exhibit these properties makes it a valuable tool in the development of new treatments for inflammatory and seizure disorders.
Used in Drug Development:
4,5-METHYLENEDIOXY-2-NITROCINNAMIC ACID is used as a candidate for drug development due to its promising properties and potential therapeutic effects. Further research and development could lead to the creation of new drugs targeting a range of medical conditions.

InChI:InChI=1/C10H7NO6/c12-10(13)2-1-6-3-8-9(17-5-16-8)4-7(6)11(14)15/h1-4H,5H2,(H,12,13)/p-1/b2-1+

Upstream product

• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 108-24-7 acetic anhydride 
• 2373-80-0 3,4-methylenedioxy-trans-cinnamic acid 
• 141-82-2 malonic acid 
• 120-57-0 piperonal 

Downstream Products

• 267-48-1 5,6-methylenedioxyindole 

Relevant academic research and scientific papers

Synthesis, chemical characterization and biological screening for cytotoxicity and antitumor activity of organotin (IV) derivatives of 3,4-methylenedioxy 6-nitrophenylpropenoic acid

A series of mono-, di- and triorganotin compounds with general formulae [RSnL2Cl], R = Bu (compound 3), [R2SnL2], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R3SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6- nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (1H-, 13C- and 119Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL2Cl] 2SnL2] 3SnL].

Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies

We herein describe the synthesis and characterization of nine new 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine. We evaluate their toxic effects against the different evolutive forms of Trypanosoma cruzi, and the host cell (murine macrophages). The results obtained show that mesoionic hydrochloride MI possesses the best activity profile. Compound MI may be a prototype for use in the development of a new chemotherapeutic agent with high efficiency, which may be employed in the treatment of Chagas' disease.