63155-11-3

Basic information

• Product Name: 2-Pyrimidineacetic acid, ethyl ester (9CI)
• Synonyms: 2-Pyrimidineacetic acid, ethyl ester (9CI);2-Pyrimidineacetic acid ethyl ester;Ethyl 2-(2-Pyrimidyl)acetate;pyriMidin-2-yl-acetic acid ethyl ester;Ethyl pyrimidine-2-acetate
• CAS NO: 63155-11-3
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 63155-11-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 238 ºC
• Flash Point: 98 ºC
• Appearance: /
• Density: 1.144
• Vapor Pressure: 0.0429mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.93±0.13(Predicted)
• CAS DataBase Reference: 2-Pyrimidineacetic acid, ethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidineacetic acid, ethyl ester (9CI)(63155-11-3)
• EPA Substance Registry System: 2-Pyrimidineacetic acid, ethyl ester (9CI)(63155-11-3)

Safety Data

• Hazardous Substances Data: 63155-11-3(Hazardous Substances Data)

Usage

General Description

2-Pyrimidineacetic acid, ethyl ester (9CI) is a chemical compound that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. It is also known for its use as a flavoring and fragrance ingredient in the production of perfumes and other scented products. 2-Pyrimidineacetic acid, ethyl ester (9CI) is a colorless liquid with a faint odor and is highly flammable. It is important to handle this chemical with caution and to follow proper safety protocols when working with it.

InChI:InChI=1/C8H10N2O2/c1-2-12-8(11)6-7-9-4-3-5-10-7/h3-5H,2,6H2,1H3

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 105-53-3 diethyl malonate 
• 164296-40-6 diethyl 2-(Pyrimidin-2-yl)malonate 

Downstream Products

• 940933-06-2 3-chloro-5-(4-chlorophenyl)-6-methyl-4-(2-pyrimidinyl)pyridazine 
• 191725-66-3 2-pyrimidin-2- ylpropan-1-ol 
• 191725-65-2 ethyl 2-pyrimidin-2-ylpropanoate 
• 940933-25-5 5-(4-chlorophenyl)-6-methyl-4-(2-pyrimidinyl)-2H-pyridazin-3-one 

Relevant articles and documents

SWEET FLAVOR MODIFIER

The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

Piperidine and tetrahydropyridine derivatives

A class of substituted piperidine and tetrahydropyridine derivatives, linked through the 4-position thereof via an alkylene chain to a fused bicyclic heteroaromatic moiety such as indolyl, and further substituted at the 1-position by an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl-alkyl, aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1Dα; receptor subtype whilst processing at least a 10-fold selective affinity for the 5-HT1Dα; receptor subtype relative to the 5-HT1Dβ; subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.