6318-71-4

Basic information

• Product Name: [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE
• Synonyms: [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE;4-(2-pyridin-2-ylethyl)aniline;Nsc31686;4-[2-(2-pyridinyl)ethyl]aniline(SALTDATA: 2HCl);4-[2-(2-pyridinyl)ethyl]aniline
• CAS NO: 6318-71-4
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 271.19
• Mol File: 6318-71-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 57 °C
• Boiling Point: 329.1°C at 760 mmHg
• Flash Point: 179.1°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.000182mmHg at 25°C
• Refractive Index: 1.619
• PKA: 5.81±0.12(Predicted)
• CAS DataBase Reference: [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE(6318-71-4)
• EPA Substance Registry System: [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE(6318-71-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6318-71-4(Hazardous Substances Data)

Usage

General Description

[4-(2-Pyridin-2-ylethyl)phenyl]amine dihydrochloride is a chemical compound that is derived from phenylamine and pyridine. It is composed of a phenyl ring with a pyridine group attached to it via an ethyl bridge. The compound exists in the form of a dihydrochloride salt, which enhances its solubility in water and stability. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various organic compounds and drugs. [4-(2-PYRIDIN-2-YLETHYL)PHENYL]AMINE DIHYDROCHLORIDE has potential applications in the development of new medications and other bioactive molecules due to its unique structural features and chemical reactivity.

InChI:InChI=1/C13H14N2/c14-12-7-4-11(5-8-12)6-9-13-3-1-2-10-15-13/h1-5,7-8,10H,6,9,14H2

Upstream product

• 24470-06-2 (E)-2-[2-(4-nitrophenyl)ethenyl]pyridine 
• 1694-46-8 (E)-4-[2-(pyridin-2-yl)ethenyl]aniline 
• 1023-67-2 2-(4-nitrostyryl)pyridine 
• 109-06-8 α-picoline 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 128616-23-9 2-nitro-4-(2-[2]pyridyl-ethyl)-aniline 
• 408365-10-6 N-(4-[2-(2-pyridinyl)ethyl]phenyl}-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide 
• 128616-21-7 N-[2-Nitro-4-(2-pyridin-2-yl-ethyl)-phenyl]-acetamide 
• 128616-26-2 2-<2-(3,4-diaminophenyl)ethyl>pyridine 

Relevant articles and documents

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 μM) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.