1023-67-2

Basic information

• Product Name: 2-[2-(4-nitrophenyl)ethenyl]pyridine
• Synonyms: 2-[2-(4-nitrophenyl)ethenyl]pyridine;2-(4-Nitrostyryl)pyridine
• CAS NO: 1023-67-2
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.23
• Mol File: 1023-67-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 356°Cat760mmHg
• Flash Point: 169.1°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 6.17E-05mmHg at 25°C
• Refractive Index: 1.694
• CAS DataBase Reference: 2-[2-(4-nitrophenyl)ethenyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4-nitrophenyl)ethenyl]pyridine(1023-67-2)
• EPA Substance Registry System: 2-[2-(4-nitrophenyl)ethenyl]pyridine(1023-67-2)

Safety Data

• Hazardous Substances Data: 1023-67-2(Hazardous Substances Data)

Usage

General Description

2-[2-(4-nitrophenyl)ethenyl]pyridine, also known as beta-nitrostyrylpyridine, is a chemical compound with the molecular formula C16H11N3O2. It is a nitroaromatic compound that contains both a nitro group and a vinyl group. 2-[2-(4-nitrophenyl)ethenyl]pyridine is often used as a building block in the synthesis of various materials, such as optical and electronic materials. It has also been studied for its potential pharmacological properties, particularly as a potential anti-cancer agent due to its ability to inhibit cell growth and induce apoptosis in cancer cells. Additionally, it has been investigated for its potential use in organic light-emitting diodes (OLEDs) and other optoelectronic applications.

InChI:InChI=1/C13H10N2O2/c16-15(17)13-8-5-11(6-9-13)4-7-12-3-1-2-10-14-12/h1-10H

Upstream product

• 109-06-8 α-picoline 
• 555-16-8 4-nitrobenzaldehdye 
• 38700-15-1 triphenyl-(2-pyridylmethyl)phosphonium chloride 
• 1121-60-4 pyridine-2-carbaldehyde 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 

Downstream Products

• 128616-21-7 N-[2-Nitro-4-(2-pyridin-2-yl-ethyl)-phenyl]-acetamide 
• 128616-31-9 2-[2-{4-(3-Ethylthioureido)phenyl}ethyl]pyridine 
• 128616-19-3 N-[4-(2-Pyridin-2-yl-ethyl)-phenyl]-acetamide 
• 128616-26-2 2-<2-(3,4-diaminophenyl)ethyl>pyridine 
• 128616-23-9 2-nitro-4-(2-[2]pyridyl-ethyl)-aniline 
• 6318-71-4 4-[2-(2-Pyridinyl)ethyl]phenylamine 

Relevant articles and documents

Iron complex containing diphosphine meta-position carborane ligand as well as preparation method and application of same

The invention relates to an iron complex containing a diphosphine meta-position carborane ligand as well as a preparation method and application of the same. The iron complex is prepared by the following method: reacting n-BuLi with m-carborane m-C2B10H12, then adding halogenated phosphine for continuous reaction, then adding FeCl2 into a reaction system for continuous reaction, after the reactionis finished, separating the reaction product to obtain an iron complex containing a diphosphine m-carborane ligand, and applying the iron complex to catalytic synthesis of a trans-2-alkenyl azaarenecompound. Compared with the prior art, the method shows efficient catalytic activity in synthesis of the trans-2-alkenyl aza-aromatic hydrocarbon compound through direct condensation reaction of 2-methyl aza-aromatic hydrocarbon and aromatic aldehyde, is low in catalyst dosage, mild in reaction condition, high in reaction rate and relatively high in yield, and has a wide application prospect in industry.

2, 4-substituted pyrimidine derivative, preparation method thereof and application thereof in preparation of antitumor drugs

The invention belongs to the field of medical compounds, and particularly relates to a 2, 4-substituted pyrimidine derivative, a preparation method thereof and an application thereof in the preparation of antitumor drugs. The derivative has a structure sh

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 μM) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.