631861-08-0

Upstream product

• 106-47-8 4-chloro-aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 93-58-3 benzoic acid methyl ester 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 

Downstream Products

• 719-59-5 5-chloro-2-aminobenzophenone 
• 30169-33-6 6-Chlor-1,2-dihydro-4-phenylchinolin-2-on 
• 1631145-03-3 tert-butyl 5-chloro-2-formyl-3-phenyl-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase

Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds were active against HIV-1 RT. Compounds 4a2 and 4d2 showed inhibitory activities with IC50 values of 0.21 and 0.15 μM, respectively, with a mode of interaction with RT residues of the allosteric pocket similar to that of efavirenz.

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively).