631862-69-6

Basic information

• Product Name: Urea, N-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-N'-pyrazinyl-
• CAS NO: 631862-69-6
• Molecular Formula: C16H20ClN5O2
• Molecular Weight: 349.82
• Mol File: 631862-69-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Urea, N-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-N'-pyrazinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-N'-pyrazinyl-(631862-69-6)
• EPA Substance Registry System: Urea, N-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-N'-pyrazinyl-(631862-69-6)

Safety Data

• Hazardous Substances Data: 631862-69-6(Hazardous Substances Data)

Upstream product

• 95-85-2 2-hydroxy-5-chloro-aniline 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 98-97-5 2-pyrazylcarboxylic acid 
• 1138-12-1 5-chloro-2-(3-dimethylaminopropoxy)phenylamine 
• 75322-66-6 pyrazine-2-carbonyl azide 

Relevant articles and documents

N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS CHK1 INHIBITORS FOR THE TREATMENT OF CANCER

The invention provides a Chk-1 kinase inhibiting compound of the formula (I) or a salt, solvate or tautomer thereof, wherein: G is CH2, O, NH, NHCO or CONH; A is a group (CH2)n where n is 1 to 4 provided that when G is O or NH, n is at least 2; X1 is nitrogen or CH; X2 is nitrogen or a group CR5; X3 is nitrogen or a group CR5; X4 is nitrogen or CH; provided that no more than two of X2, X3 and X4 are nitrogen; and R1; R2; R3; R4;R5 and R6 are as defined in the claims.

DIARYLUREA COMPOUNDS AND DERIVATIVES AS CHK-1 INHIBITORS FOR THE TREATMENT OF CANCER

Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.