6319-32-0Relevant articles and documents
Azaisoflavones: Synthesis, antimicrobial evaluation and binding affinity with DNA gyrase
Praveen,Parthasarathy,Kumar, P. Senthil,Perumal
, p. 373 - 382 (2015/03/31)
Antimicrobial potency of azaisoflavones has been evaluated in vitro against nine bacterial and two fungal strains, respectively. The requisite azaisoflavones are conveniently synthesized in three steps, with the key step being the super acid catalyzed tandem reaction. The biological results reveal that out of twelve compounds screened, 3 compounds (5a, 5j and 5l) exhibited comparable activities against the standard drugs and demonstrated activities at μM concentration. In addition, molecular docking revealed that compound 5a as the most potent by showing a least binding energy of -5.99 kcal/mol with DNA gyrase receptor compared to other compounds.
C-H arylation of pyridines: High regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring
Guo, Pengfei,Joo, Jung Min,Rakshit, Souvik,Sames, Dalibor
supporting information; experimental part, p. 16338 - 16341 (2011/11/29)
We report a new catalytic protocol for highly selective C-H arylation of pyridines containing common and synthetically versatile electron-withdrawing substituents (NO2, CN, F and Cl). The new protocol expands the scope of catalytic azine functi
Synthesis of 4-Aryl-2-aminopyridine derivatives and related compounds
Pavlovic, Vladimir,Petkovic, Milos,Popovic, Stanimir,Savic, Vladimir
experimental part, p. 4249 - 4263 (2010/01/15)
A short, efficient, and high-yielding synthesis of 4-aryl-2-aminopyridine derivatives has been developed. The route employs two palladium-catalyzed processes, the Suzuki reaction and the Buchwald-Hartwig amination, as the key steps. The same approach has