63194-78-5

Upstream product

• 533-31-3 Sesamol 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 113470-96-5 (6R,7R,8S)-6-Ethoxy-8-(4-methoxy-phenyl)-7-methyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 63194-75-2 rac-(6S,8R)-6-ethoxy-8-(4-methoxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 100044-70-0 (E)-6-(4-methoxybenzylidene)-3,4-methylenedioxy-2,4-cyclohexadien-1-one 
• 63194-75-2 6-ethoxy-8-(4-methoxy-phenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 63194-80-9 3,4-dimethoxy-6-(4-methoxyphenylmethylidene)cyclohexa-2,4-dien-1-one 
• 126935-10-2 10-(4-Methoxy-phenyl)-6,7,8,10-tetrahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 

Relevant academic research and scientific papers

Highly Stereoselective Construction of β,β-Diaryl-α-Branched Ketones by the Chiral Primary Amine-Catalyzed Asymmetric Retro-Claisen Reaction

Highly diastereo- and enantioselective retro-Claisen reaction of β-diketones with o-quinone methides has been developed by chiral primary amine catalysis. This reaction allows for efficient synthesis of chiral β,β-diaryl-α-branched ketones in moderate to good yields with excellent stereoselectivities. The reaction occurs via a tandem sequence of benzylic C-C bond formation, C-C bond cleavage, and stereospecific enamine protonation. This strategy uses o-quinone methides as diaryl precursors and features a broad substrate scope, mild conditions, and a high degree of stereocontrol.

Organophotoredox-catalyzed intermolecular Oxa-[4+2] cycloaddition reactions

An intermolecular oxa-[4+2] cycloaddition reaction promoted by a thioxanthylium photoredox catalyst under irradiation with green light has been developed. The reaction of ortho-quinone methides with styrenes smoothly affords the desired cycloadducts. Espe

A one-pot oxidation/cycloaddition cascade synthesis of 2,4-diaryl chromans via ortho-quinone methides

A one-pot oxidation/cycloaddition cascade for the synthesis of 2,4-diaryl chromans is developed. The reaction involves in situ oxidative generation of the unstable o-quinone methides followed by endo selective [4+2] cycloaddition with styrenes.

Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile

2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes with excellent yields and enantioselectivities. Moreover, this reaction can be performed in up to 6 mmol scale without any noticeable loss of yield and stereoselectivity. This journal is

Conversion of substituted benzyl ethers to diarylmethanes. A direct synthesis of diarylbenzofurans

The Lewis acid catalyzed rearrangement of substituted benzyl ethers affords diarylmethanes in good yields. One of the products was converted into a diarylbenzofuran using a benzoylation/P4-tBu cyclization protocol.