63194-78-5

Basic information

• Product Name: 6-(4-methoxybenzyl)-1,3-benzodioxol-5-ol
• CAS NO: 63194-78-5
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.2693
• Mol File: 63194-78-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 423.7°C at 760 mmHg
• Flash Point: 210.1°C
• Density: 1.275g/cm³
• Vapor Pressure: 8.87E-08mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 6-(4-methoxybenzyl)-1,3-benzodioxol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methoxybenzyl)-1,3-benzodioxol-5-ol(63194-78-5)
• EPA Substance Registry System: 6-(4-methoxybenzyl)-1,3-benzodioxol-5-ol(63194-78-5)

Safety Data

• Hazardous Substances Data: 63194-78-5(Hazardous Substances Data)

Upstream product

• 533-31-3 Sesamol 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 63194-80-9 3,4-dimethoxy-6-(4-methoxyphenylmethylidene)cyclohexa-2,4-dien-1-one 
• 63194-75-2 6-ethoxy-8-(4-methoxy-phenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 100044-70-0 (E)-6-(4-methoxybenzylidene)-3,4-methylenedioxy-2,4-cyclohexadien-1-one 
• 63194-75-2 rac-(6S,8R)-6-ethoxy-8-(4-methoxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 1601467-13-3 7-(4-methoxyphenyl)-6,7-dihydrobenzofuro[6,5-d][1,3]dioxole 
• 1601467-18-8 (7-(4-methoxyphenyl)benzofuro[6,5-d][1,3]dioxol-6-yl)(phenyl)methanone 
• 126935-10-2 10-(4-Methoxy-phenyl)-6,7,8,10-tetrahydro-1,3,5-trioxa-cyclopenta[b]anthracen-9-one 

Relevant articles and documents

Highly Stereoselective Construction of β,β-Diaryl-α-Branched Ketones by the Chiral Primary Amine-Catalyzed Asymmetric Retro-Claisen Reaction

Highly diastereo- and enantioselective retro-Claisen reaction of β-diketones with o-quinone methides has been developed by chiral primary amine catalysis. This reaction allows for efficient synthesis of chiral β,β-diaryl-α-branched ketones in moderate to good yields with excellent stereoselectivities. The reaction occurs via a tandem sequence of benzylic C-C bond formation, C-C bond cleavage, and stereospecific enamine protonation. This strategy uses o-quinone methides as diaryl precursors and features a broad substrate scope, mild conditions, and a high degree of stereocontrol.

A one-pot oxidation/cycloaddition cascade synthesis of 2,4-diaryl chromans via ortho-quinone methides

A one-pot oxidation/cycloaddition cascade for the synthesis of 2,4-diaryl chromans is developed. The reaction involves in situ oxidative generation of the unstable o-quinone methides followed by endo selective [4+2] cycloaddition with styrenes.

Conversion of substituted benzyl ethers to diarylmethanes. A direct synthesis of diarylbenzofurans

The Lewis acid catalyzed rearrangement of substituted benzyl ethers affords diarylmethanes in good yields. One of the products was converted into a diarylbenzofuran using a benzoylation/P4-tBu cyclization protocol.