63194-80-9

Usage

Uses

Used in Pharmaceutical Industry:
(6E)-6-[(4-methoxyphenyl)methylidene]-1,3-benzodioxol-5(6H)-one is used as a potential pharmaceutical candidate for [application reason] due to its unique chemical structure and properties.
Used in Chemical Industry:
(6E)-6-[(4-methoxyphenyl)methylidene]-1,3-benzodioxol-5(6H)-one is used as a chemical intermediate or building block for the synthesis of other compounds for [application reason] due to its specific functional groups and reactivity.
Note: The specific applications and reasons for using (6E)-6-[(4-methoxyphenyl)methylidene]-1,3-benzodioxol-5(6H)-one in the pharmaceutical or chemical industries would need to be further investigated through research and testing.

Upstream product

• 63194-78-5 2-(4-Methoxybenzyl)-4,5-(methylenedioxy)phenol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2033-89-8 3,4-dimethoxyphenol 
• 63194-79-6 6-(4-methoxybenzyl)benzo[d][1,3]dioxol-5-ol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 4720-68-7 4,5-methylenedioxy-2-hydroxybenzaldehyde 
• 533-31-3 Sesamol 

Downstream Products

• 113470-96-5 (6R,7R,8S)-6-Ethoxy-8-(4-methoxy-phenyl)-7-methyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene 
• 1214787-23-1 (7R,8S)-7-(4-chlorophenyl)-7-ethyl-8-(4-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-22-0 (7R,8S)-7-ethyl-7,8-bis(4-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-24-2 (7R,8S)-7-(4-bromophenyl)-7-ethyl-8-(4-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-15-1 7-ethyl-8-(4-methoxyphenyl)-7-phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 2294-71-5 methyl 2-phenylbutanoate 
• 1214787-21-9 (7R,8S)-7-ethyl-8-(4-methoxyphenyl)-7-p-tolyl-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-25-3 (7R,8S)-7-ethyl-8-(4-methoxyphenyl)-7-(naphthalen-2-yl)-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-16-2 (7S,8R)-7-ethyl-8-(4-methoxyphenyl)-7-phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 
• 1214787-14-0 (7R,8S)-7-ethyl-8-(4-methoxyphenyl)-7-phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]coumarin 

Relevant academic research and scientific papers

Asymmetric Catalytic [4+5] Annulation of ortho-Quinone Methides with Vinylethylene Carbonates and its Extension to Stereoselective Tandem Rearrangement

Palladium-catalyzed asymmetric [4+5] annulation of ortho-quinone methides (o-QMs) with substituted vinylethylene carbonates (VECs) is described for the first time, giving a novel enantioselective approach to chiral nine-membered benzoheterocycles. Based on this designed [4+5] annulation, an unprecedented silica gel-promoted tandem rearrangement reaction featuring a unique asymmetric aromatic Claisen rearrangement is explored at room temperature, offering a new method for asymmetric construction of all-carbon quaternary stereocenters embedded in chiral functionalized homoallylic alcohols.

Highly Regio-, Diastereo-, and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium-Catalyzed [4+3] Cycloaddition Reactions

A novel Pd0-catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo-, and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines.

Organophotoredox-catalyzed intermolecular Oxa-[4+2] cycloaddition reactions

An intermolecular oxa-[4+2] cycloaddition reaction promoted by a thioxanthylium photoredox catalyst under irradiation with green light has been developed. The reaction of ortho-quinone methides with styrenes smoothly affords the desired cycloadducts. Espe

Transition-Metal-Free [4+3]-Cycloaddition of ortho-Quinone Methides and Isomünchnones: Catalytic and Diastereoselective Assembly of Oxa-bridged Oxazocine Scaffolds

Cycloadditions are powerful processes to synthesize complex polycyclic scaffolds. Herein, we disclose a [4+3]-cycloaddition between an in situ generated ortho-quinone methide and an isomünchnone to yield oxa-bridged oxazocine cores, generating N2 and H2O as the sole by-products. Using only catalytic amounts of camphorsulfonic acid, it is possible to generate both reactive intermediates in one step, eliminating the need for rhodium catalysts generally employed for isomünchnone formation. Spectroscopic data and X-ray crystallography indicate the formation of the syn diastereomer, with the main side-product arising from a hydrate participating in a competing [4+2]-cycloaddition pathway.

N-Heterocyclic Carbene-Catalyzed [4 + 2] Cyclization of Saturated Carboxylic Acid with o-Quinone Methides through in Situ Activation: Enantioselective Synthesis of Dihydrocoumarins

An N-heterocyclic carbene (NHC)-catalyzed formal [4 + 2] synthesis of dihydrocoumarins was realized from saturated carboxylic acids and o-quinone methides via an in situ activation strategy. This protocol results in excellent diastereoselectivity and enantioselectivity and good yields and uses readily available and inexpensive starting materials.

Formal Asymmetric Catalytic Thiolation with a Bifunctional Catalyst at a Water-Oil Interface: Synthesis of Benzyl Thiols

The enantioselective conjugated addition of tritylthiol to in situ generated ortho-quinone methides (o-QMs) is catalyzed by an acid-base bifunctional squaramide organocatalyst. The transformation proceeds with high yield (up to 99%) and stereoselectivity (up to 97:3 e.r.) using water as solvent under mild conditions. The catalyst system provides a new strategy for the synthesis of optically active benzyl mercaptans. Control experiments suggested that o-QMs are generated by the tertiary amine moiety of the squaramide organocatalyst and that the water-oil biphase is crucial for achieving high reactivity and stereoselectivity.