63199-74-6 Usage
Uses
Used in Pharmaceutical Industry:
2-(TERT-BUTYLAMINO)PROPIOPHENONE HYDROCHLORIDE is used as an active pharmaceutical ingredient for its antidepressant-like activity. It serves as a deschloro analogue of Bupropion, a selective dopamine uptake inhibitor, which makes it a promising candidate for the development of new antidepressant medications.
Used in Research and Development:
In the field of neuroscience and pharmacology, 2-(TERT-BUTYLAMINO)PROPIOPHENONE HYDROCHLORIDE is used as a research compound to study the effects of dopamine uptake inhibition on mood and behavior. This helps researchers understand the underlying mechanisms of depression and develop more effective treatments.
Used in Drug Formulation:
2-(TERT-BUTYLAMINO)PROPIOPHENONE HYDROCHLORIDE can be utilized in the formulation of new drugs targeting depression and other mood disorders. Its selective action on dopamine uptake makes it a valuable component in the development of medications with fewer side effects and improved efficacy compared to existing treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 63199-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,9 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 63199-74:
(7*6)+(6*3)+(5*1)+(4*9)+(3*9)+(2*7)+(1*4)=146
146 % 10 = 6
So 63199-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO.ClH/c1-10(14-13(2,3)4)12(15)11-8-6-5-7-9-11;/h5-10,14H,1-4H3;1H
63199-74-6Relevant academic research and scientific papers
Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release
Shalabi, Abdelrahman R.,Walther, Donna,Baumann, Michael H.,Glennon, Richard A.
, p. 1397 - 1403 (2017/06/27)
Bupropion (1), an α-aminophenone uptake inhibitor at plasma membrane transporters for dopamine (DAT) and norepinephrine (NET), is a widely prescribed antidepressant and smoking cessation aid. Cathinone (2), a structurally simpler α-aminophenone, is a substrate-type releasing agent at the same transporters and a recognized drug of abuse. Our goal was to identify the structural features of α-aminophenones that govern the mechanistic transition from uptake inhibition to substrate-induced release. Deconstructed analogues of 1 were synthesized and compared for their ability to interact with DAT, NET, and the serotonin transporter (SERT) using in vitro assay methods. Bulky amine substituents resulted in compounds that function as DAT uptake inhibitors but not release agents, whereas smaller amine substituents result in relatively nonselective releasing agents at DAT and NET. Our findings add to empirical evidence supporting distinct molecular determinants for α-aminophenone- (i.e., cathinone-) related agents acting as transporter inhibitors versus those acting as releasers.
