632-99-5

Basic information

• Product Name: FUCHSIN BASIC
• Synonyms: 12418red;4-((4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl)-2-benzenamin;abcolmagentaabnconc;aizenmagenta;astrafuchsineb;basicfuchsine;Basicmagenta;basicmagentae-200
• CAS NO: 632-99-5
• Molecular Formula: C₂₀H₂₀N₃*Cl
• Molecular Weight: 337.85
• EINECS: 211-189-6
• Product Categories: Dyes and Pigments;Triphenylmethane
• Mol File: 632-99-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 589.3 °C at 760 mmHg
• Flash Point: 48 °F
• Appearance: Green to dark green/liquid
• Density: 0.999 g/mL at 20 °C
• Vapor Pressure: 5.41E-13mmHg at 25°C
• Refractive Index: n20/D 1.334
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble1mg/mL
• Water Solubility: 4 G/L (25 ºC)
• Merck: 14,5652
• BRN: 4166684
• CAS DataBase Reference: FUCHSIN BASIC(CAS DataBase Reference)
• NIST Chemistry Reference: FUCHSIN BASIC(632-99-5)
• EPA Substance Registry System: FUCHSIN BASIC(632-99-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 40-22
• Safety Statements: 7-16-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• RTECS: CX9850000
• TSCA: Yes
• Hazardous Substances Data: 632-99-5(Hazardous Substances Data)

Usage

Chemical Properties

Green crystal powder

Uses

Different sources of media describe the Uses of 632-99-5 differently. You can refer to the following data:
1. As a dye or in manufacture of other dyes.
2. Biological stain for distinguishing coli and aerogene bacteriaBasic Fuchsin is useful for Ziehl-Neelson staining to detect acid-fast bacilli. It is also used to stain tubercle bacillus and bacterial flagella. It plays an important role for tissue sections to visualize elastic fibers, cardiac and skeletal muscle tissue. It also acts as bacterial and histological stains. Further, it is used to stain cellular elements, certain tissues, bacteria and also acts as a local anti-infective.

Definition

ChEBI: A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.

General Description

Dark green powder. A dye derived from triphenylmethane.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

FUCHSIN BASIC neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Easily reduced to colorless leuco-bases .

Fire Hazard

Flash point data for FUCHSIN BASIC are not available, but FUCHSIN BASIC is probably combustible.

Flammability and Explosibility

Notclassified

Clinical Use

Basic fuchsin is a mixture of the chlorides of rosaniline andp-rosaniline. It exists as a green crystalline powder with ametallic appearance. The compound is soluble in water andin alcohol but insoluble in ether. Basic fuchsin is a componentof carbol–fuchsin solution (Castellani’s paint), which isused topically in the treatment of fungal infections, notablyringworm and athlete’s foot.

Properties and Applications

TEST ITEMS SPECIFICATION APPEARANCE VIOLET LIGHTING 4-5 SOAPING 4-5 PERSPIRATING 4-5 FRICTION(DRY) 4-5 FRICTION(WET) 4 RESIDUE ON 80 MESH 5.0% max WATER SOLUBLE 1.0% max VOLATITE 105 °C 1.0% max TINTING STRENGTH 100-105 % WEIGHT METAL TOTAL 50ppm max

TEST ITEMS

SPECIFICATION

APPEARANCE

VIOLET

RESIDUE ON 80 MESH

5.0% max

WATER SOLUBLE

1.0% max

VOLATITE 105 °C

1.0% max

TINTING STRENGTH

100-105 %

WEIGHT METAL TOTAL

50ppm max

Purification Methods

Purify the dye by dissolving it in EtOH, filtering and adding H2O. Filter or centrifuge it and wash the precipitate with Et2O and dry it in air. It has also been recrystallised from water and dried in vacuo at 40o. The crystals have a metallic green lustre. It has UV max in EtOH at 543nm ( 93,000). Its solubility in H2O is 0.26%. A carmine red colour is obtained in EtOH. It is paraRosaniline with a methyl group. [Scalan J Am Chem Soc 57 887 1937.]

InChI:InChI=1/C20H19N3.ClH/c1-13-12-16(6-11-19(13)23)20(14-2-7-17(21)8-3-14)15-4-9-18(22)10-5-15;/h2-12,23H,21-22H2,1H3;1H

Synthetic route

sodium dodecyl-sulfate (151-21-3) + 4-[(4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methylaniline hydrochloride (632-99-5) → dodecylsulphate rosaniline hydrochloride 1:1 complex

Conditions	Yield
In water

4-[(4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methylaniline hydrochloride (632-99-5) → (4-Amino-3-methyl-phenyl)-bis-(4-amino-phenyl)-methanol (76-82-4)

Conditions	Yield
With sodium hydroxide at 30℃; Kinetics; Further Variations:; in the presence of inorganic salts;

Downstream Products

• 76-82-4 (4-Amino-3-methyl-phenyl)-bis-(4-amino-phenyl)-methanol 

Relevant articles and documents

Use of aromatic compounds as phase directors and particle size reducers for quinacridone pigments

The present invention relates to a process for producing alpha, gamma-I, gamma-II and gamma-III crystal modifications of quinacridone and transparent quinacridone pigments including the solid solutions of various quinacridones, using a variety of tris-aryl-s-triazines, particularly resorcinol triazine derivatives, or aromatic- or heteraromatic-compounds having at least one hydroxyl or keto group bonded to the ring, as an additive, prior to or concurrently with the oxidation of corresponding dihydroquinacridone salts.