6320-26-9

Usage

Chemical class

Piperazine derivative

Structure

Substituted phenyl ring and a chloropropyl group attached to the piperazine nitrogen atom

Medicinal use

Psychoactive drug

Potential treatments

Depression, anxiety, and schizophrenia

Research applications

Biochemical and pharmacological studies to understand effects on the central nervous system

Neurotransmitter interactions

Serotonin and dopamine receptors

Therapeutic potential

Possible future uses in medicine

Psychoactive effects

May have potential for abuse

Regulation

Requires careful consideration and regulation due to psychoactive properties

Upstream product

• 41186-03-2 1-(3-Methylphenyl)piperazine 
• 109-70-6 1.3-chlorobromopropane 
• 7511-73-1 1-(3-hydroxy-n-propyl)-4-(3-methylphenyl)piperazine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 119696-36-5 1-(4-phenyl-piperazino)-3-(4-m-tolyl-piperazino)-propane 
• 116030-52-5 1-(4-m-tolyl-piperazino)-3-(4-p-tolyl-piperazino)-propane 
• 6320-28-1 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 6320-29-2 1-[4-(4-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 116030-90-1 1-(4-m-tolyl-piperazino)-3-(4-o-tolyl-piperazino)-propane 
• 114694-59-6 1-[4-(2-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 103076-65-9 2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-benzaldehyde 
• 103074-42-6 2-{2-[3-(4-m-Tolyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide 
• 91532-14-8 3-[3-(4-m-Tolyl-piperazin-1-yl)-propyl]-3H-benzo[d][1,2,3]triazin-4-one 

Relevant academic research and scientific papers

Benzo- and thieno-triazine-1,2,3 ones-4

This invention relates to benzo- and thieno-triazine-1,2,3 ones-4 represented by the formula STR1 in which m is 2, 3 or 4, X is the vinylene group --CH=CH-- or a sulfur atom; R1 and R2 can be alike or different and are hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or trifluoromethyl radical; when X is --CH--CH-- n is 0, 1 or 2 and R is hydrogen, halogen, a lower alkyl radical, lower alkoxy radical or nitro group; when X is a sulfur atom, R is hydrogen or constitutes a --CH2 --4 chain between the two open positions of the thiophenic ring. The compounds are useful as antidepressant drugs.

N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.