63220-44-0

Basic information

• Product Name: 2H-Indol-2-one, 7-bromo-1,3-dihydro-3-hydroxy-3-phenyl-
• CAS NO: 63220-44-0
• Molecular Formula: C14H10BrNO2
• Molecular Weight: 304.143
• Mol File: 63220-44-0.mol

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 7-bromo-1,3-dihydro-3-hydroxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 7-bromo-1,3-dihydro-3-hydroxy-3-phenyl-(63220-44-0)
• EPA Substance Registry System: 2H-Indol-2-one, 7-bromo-1,3-dihydro-3-hydroxy-3-phenyl-(63220-44-0)

Safety Data

• Hazardous Substances Data: 63220-44-0(Hazardous Substances Data)

Upstream product

• 20780-74-9 7-bromoisatin 
• 100-59-4 phenylmagnesium chloride 
• 841-76-9 triphenylaluminium 
• 100-58-3 phenylmagnesium bromide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 793728-14-0 2-amino-3-[3-(7-bromo-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-phenyl]-propionic acid methyl ester 
• 496789-41-4 2-acetylamino-3-[3-(7-bromo-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-phenyl]-propionic acid methyl ester 
• 866993-76-2 7-bromo-3-chloro-3-phenyl-1,3-dihydroindol-2-one 
• 866993-78-4 7-bromo-3-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-dihydroindol-2-one 
• 866993-77-3 7-bromo-3-phenyl-3-p-tolyloxy-1,3-dihydroindol-2-one 

Relevant articles and documents

Total synthesis of diazonamide A

Ever since its discovery in 1991, diazonamide A (1) has been eyed by synthetic chemists as a potential target because of its puzzling molecular architecture and potent biological activity. The race to synthesize this intriguing natural product was further

Catalyst-free synthesis of 3-hydroxy-3-(alkyl/aryl)indolin-2-ones by addition of organoaluminum reagents to isatins

An efficient synthesis of 3-hydroxy-3-(alkyl/aryl)indol-2-one derivatives has been described by the reactions of isatin with organoaluminum reagents. The reaction is very rapid and yields are high. The protocol is applicable for substituted isatins as well as a variety of organoaluminums.

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

Chemistry and biology of diazonamide A: First total synthesis and confirmation of the true structure

With the addition of a tenth ring, the exchange of an oxygen atom for a nitrogen in the heart of the molecule, and a different terminal residue, the revised architecture for diazonamide A (1) provided an even more challenging molecular puzzle for chemical synthesis than its predecessor. In this article, we detail the first successful total synthesis of diazonamide A, an endeavor which not only verified its proper connectivities and established the stereochemistry of its previously unassignable C-37 chiral center, but which also was attended by the development of several new synthetic strategies and tactics.

7-Substituted-2-indolinones

The compounds are 7-substituted-2-indolinones which are useful as anticonvulsant agents. Representative of the compounds are 7-chloro-3-hydroxy-3-phenyl-indolin-2-one, 7-bromo-3-hydroxy-3-phenyl-2-indolinone, and 7-chloro-3-hydroxy-3-methyl-2-indolinone.