63223-87-0Relevant academic research and scientific papers
Synthesis of 20S-Protopanaxatriol β-D-Glucopyranosides
Atopkina,Denisenko
, p. 82 - 87 (2019)
Condensation of 20S-protopanaxatriol (3β,6α,12β,20S-tetrahydroxydammar-24-ene) (1) with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (2) in the presence of Ag2O in CH2Cl2 gave a mixture of acetylated 3-, 12-, 20-, 3,12-di-, and 3,20-di-O-β-D-glucopyranosides 3–7 that was dominated by 3-O-β-Dglucopyranoside tetraacetate 3 (47%). Subsequent deacetylation by sodium methoxide produced free β-D-glucopyranosides 8–12, three of which were identical to chikusetsusaponin-L10, ginsenoside-F1, and ginsenoside-Ia, which were isolated earlier from leaves of Panax japonicus and P. ginseng. 3-Mono- and 3,12-di-O-β-D-glucopyranosides 8 and 11 were prepared for the first time.
Synthetic access toward the diverse ginsenosides
Yu, Jun,Sun, Jiansong,Niu, Yiming,Li, Rongyao,Liao, Jinxi,Zhang, Fuyi,Yu, Biao
, p. 3899 - 3905 (2013/09/23)
All the possible types of the protopanaxatriol and protopanaxadiol glycosides, the major active yet extremely heterogeneous principles of ginsengs, could be accessed by the present sequence of transformations, including global removal of the sugar residue
