632322-62-4

Basic information

• Product Name: 1-(cyclohexoxycarbonyloxy)ethyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-benzimidazole-4-carboxylate
• CAS NO: 632322-62-4
• Molecular Formula: C₃₃H₃₃N₃O₆
• Molecular Weight: 567.63
• Mol File: 632322-62-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 776.3°C at 760 mmHg
• Flash Point: 423.3°C
• Density: 1.25g/cm³
• Vapor Pressure: 4.89E-24mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 1-(cyclohexoxycarbonyloxy)ethyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-benzimidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclohexoxycarbonyloxy)ethyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-benzimidazole-4-carboxylate(632322-62-4)
• EPA Substance Registry System: 1-(cyclohexoxycarbonyloxy)ethyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-benzimidazole-4-carboxylate(632322-62-4)

Safety Data

• Hazardous Substances Data: 632322-62-4(Hazardous Substances Data)

Upstream product

• 139481-44-0 methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 632322-61-3 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid 
• 99464-83-2 1-chloroethyl cyclohexyl carbonate 

Downstream Products

• 145040-37-5 candesartan cilexetil 

Relevant articles and documents

Candesartan cilexetil preparation method

The invention provides a novel candesartan cilexetil synthesizing path which comprises the steps of carrying out alkylation reaction on 2-ethoxy benzimidazole-7-alkyl formate and 4-bromomethyl-2'-cyano biphenyl, then hydrolyzing an ester group, then reacting with 1-halogenated ethyl cyclohexyl carbonate ester to obtain an intermediate of 1-[(2'-cyano biphenyl-4-yl) methyl)-2-ethoxy-1H-benzimidazole-7-alkyl carboxylate and then obtaining candesartan cilexetil through tetrazole reaction. The novel candesartan cilexetil synthesizing path disclosed by the invention can finish alkylation, hydrolysis and ester production reaction through a one-pot method and has a few synthesizing steps and simple technology; used raw materials are easy to obtain, production cost is low, three wastes are less, and greenness and environmental friendliness are realized.