632327-21-0

Basic information

• Product Name: Benzenepropanoic acid, 3-chloro-b-hydroxy-, methyl ester
• CAS NO: 632327-21-0
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Mol File: 632327-21-0.mol

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 3-chloro-b-hydroxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 3-chloro-b-hydroxy-, methyl ester(632327-21-0)
• EPA Substance Registry System: Benzenepropanoic acid, 3-chloro-b-hydroxy-, methyl ester(632327-21-0)

Safety Data

• Hazardous Substances Data: 632327-21-0(Hazardous Substances Data)

Upstream product

• 632327-19-6 methyl 3-(3-chlorophenyl)-3-oxopropanoate 
• 99-02-5 3'-Chloroacetophenone 
• 64-17-5 ethanol 

Downstream Products

• 40620-64-2 3-hydroxy-3-(3'-chlorophenyl)propionic acid 
• 632327-22-1 (S)-(-)-methyl 3-(acetyloxy)-3-(3-chlorophenyl)propanoate 
• 632327-23-2 (R)-(+)-methyl 3-(acetyloxy)-3-(3-chlorophenyl)propanoate 
• 135505-20-3 (S)-(-)-methyl 3-(3-chlorophenyl)-3-hydroxypropanoate 
• 135505-20-3 (R)-(+)-methyl 3-(3-chlorophenyl)-3-hydroxypropanoate 
• 879492-91-8 methyl 3-(acetyloxy)-3-(3-chlorophenyl)propanoate 

Relevant articles and documents

Studies on the chemoenzymatic synthesis of (R)- and (S)-methyl 3-aryl-3-hydroxypropionates: The influence of toluene-pretreatment of lipase preparations on enantioselective transesterifications

Two series (para- and meta-substituted) of racemic methyl esters of 3-aryl-3-hydroxypropionic acid were prepared after which the enantiomers were separated by an enzyme-catalyzed transesterification. Several lipases were investigated as the catalyst. The influence of the enzyme pretreatment, as well as substrate concentration, reaction temperature, stirring manner, and substrate conversion on the stereochemical outcome of the biotransformation process were investigated in detail. The best results were achieved by using solvent-pretreated lipase from Pseudomonas fluorescens or Burkholderia cepacia suspended in toluene, and vinyl acetate as the acetyl group donor.

NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES

Novel 2'-C-methyl nucleoside 5 '-monophosphate and 4'-C-methyl nucleoside 5'- monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral inf

Novel 2'-C-methyl nucleoside derivatives

Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described: