632352-56-8

Basic information

• Product Name: 1-Boc-3-phenylpiperidin-4-one
• Synonyms: 1-BOC-3-PHENYL-PIPERIDIN-4-ONE;tert-butyl 4-Oxo-3-phenylpiperidine-1-carboxylat;tert-butyl 4-oxo-3-phenylpiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-oxo-3-phenyl-, 1,1-diMethylethyl ester
• CAS NO: 632352-56-8
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.34
• Mol File: 632352-56-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 93-94 °C
• Boiling Point: 400.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• Refractive Index: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.03±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-phenylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-phenylpiperidin-4-one(632352-56-8)
• EPA Substance Registry System: 1-Boc-3-phenylpiperidin-4-one(632352-56-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 632352-56-8(Hazardous Substances Data)

Usage

General Description

1-Boc-3-phenylpiperidin-4-one, also known as N-tert-butoxycarbonyl-3-phenyl-4-piperidone, is a chemical compound with the molecular formula C19H25NO3. It is commonly used in the synthesis of pharmaceuticals and research chemicals. Its nitrogen-containing piperidone ring makes it a valuable precursor for the creation of various bioactive compounds, including potential drug candidates. The Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom plays a crucial role in controlling the reactivity of the molecule during organic synthesis. This versatile compound has potential applications in medicinal chemistry and drug discovery research. However, it should be handled with care and caution due to its potential health hazards and reactivity.

InChI:InChI=1/C16H21NO3/c1-16(2,3)20-15(19)17-10-9-14(18)13(11-17)12-7-5-4-6-8-12/h4-8,13H,9-11H2,1-3H3

Upstream product

• 1384264-55-4 C₂₁H₂₃NO₃ 
• 1345345-81-4 1-benzyl-3-phenyl-4-piperidone hydrochloride 
• 108-86-1 bromobenzene 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 910875-39-7 4-oxo-3-phenylpiperidine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 446302-83-6 1-N-benzyl-3-phenyl-4-piperidone 

Downstream Products

• 880135-38-6 tert-butyl (3R,4S)-4-amino-3-phenylpiperidine-1-carboxylate 
• 913252-06-9 tert-butyl (3S,4R)-4-amino-3-phenylpiperidine-1-carboxylate 

Relevant articles and documents

Oxidation of Nonactivated Anilines to Generate N-Aryl Nitrenoids

A low-temperature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycles. The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol percent Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrate the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity, and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES

Disclosed are compounds of Formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6,R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

NK1 and NK3 antagonists

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-mediated conditions.