446302-83-6

Usage

Uses

Used in Recreational Drug Use:
1-Benzyl-3-phenylpiperidin-4-one is used as a recreational drug for its stimulant effects, providing users with increased energy, alertness, and a sense of euphoria.
Used in Pharmaceutical Research:
Although BZP has been banned for recreational use, it may still be utilized in pharmaceutical research for its potential applications in the development of new medications, particularly those targeting the serotonin-norepinephrine-dopamine reuptake mechanism.

InChI:InChI=1/C18H19NO/c20-18-11-12-19(13-15-7-3-1-4-8-15)14-17(18)16-9-5-2-6-10-16/h1-10,17H,11-14H2

Upstream product

• 907997-09-5 2-phenyl-1,4-pentadien-3-one 
• 100-46-9 benzylamine 
• 907997-19-7 2-phenyl-1,4-pentadien-3-ol 
• 76886-55-0 Acetophenone 2,4,6-triisopropylbenzenesulphonyl hydrazone 
• 98-86-2 acetophenone 
• 100-39-0 benzyl bromide 
• 1384264-55-4 C₂₁H₂₃NO₃ 
• 632352-54-6 3-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-2-phenyl-propionic acid ethy ester 
• 632352-55-7 ethyl 1-benzyl-4-hydroxy-5-phenyl-1,2,5,6-tetrahydro-3-pyridine carboxylate 

Downstream Products

• 76041-09-3 3-phenyl-4-piperidone 
• 1345346-06-6 C₁₈H₁₉BrN₂O 
• 1345346-05-5 (3R,4S)-4-[(4-bromobenzoyl)amino]-N-ethyl-3-phenyl-1-piperidinecarboxamide 
• 1345345-81-4 1-benzyl-3-phenyl-4-piperidone hydrochloride 
• 910875-39-7 4-oxo-3-phenylpiperidine hydrochloride 
• 1271738-27-2 4-(hydroxyimino)-3-phenylpiperidine-1-carboxylic acid tert-butyl ester 
• 632352-60-4 (±)-tert-butyl 4-amino-3-phenylpiperidine-1-carboxylate 

Relevant academic research and scientific papers

Development of κ opioid receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: Structure-activity relationship study of matrine type alkaloids

A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety of phenyl substituents and evaluated for their anti

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethyl)- 1Htetrazol-1-yl]benzyl}amino)-3-phenyl-1-piperidinyl]-2-oxoethyl}acetamide ((+)-39) was found to be one of the most potent tachykinin NK1 receptor antagonists with high metabolic stability. Highly efficient asymmetric synthesis of (+)-39 was achieved via dynamic kinetic resolution.

Synthesis of 3-phenyl-4-piperidones from acetophenone by shapiro and azamichael reactions and their further derivatization

The Shapiro reaction of acetophenone is the key in a convenient three-step access to a divinyl ketone which is further transformed by double aza-Michael reactions with primary amines into N-substituted 3-phenyl-4-piperidones. In the case of N-benzyl and N

PIPERIDINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a compound represented by the formula: ???wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydroca