632362-08-4Relevant academic research and scientific papers
Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase
Popovici-Muller, Janeta,Shipps Jr., Gerald W.,Rosner, Kristin E.,Deng, Yongqi,Wang, Tong,Curran, Patrick J.,Brown, Meredith A.,Siddiqui, M. Arshad,Cooper, Alan B.,Duca, Jose,Cable, Michael,Girijavallabhan, Viyyoor
, p. 6331 - 6336 (2009)
The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.
