632365-56-1

Basic information

• Product Name: Ethanone, 1-(3-phenoxyphenyl)-2-phenyl-
• CAS NO: 632365-56-1
• Molecular Formula: C20H16O2
• Molecular Weight: 288.346
• Mol File: 632365-56-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(3-phenoxyphenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-phenoxyphenyl)-2-phenyl-(632365-56-1)
• EPA Substance Registry System: Ethanone, 1-(3-phenoxyphenyl)-2-phenyl-(632365-56-1)

Safety Data

• Hazardous Substances Data: 632365-56-1(Hazardous Substances Data)

Upstream product

• 65261-14-5 N,N'-Diisopropyl-3-phenoxy-benzamid 
• 108-88-3 toluene 

Relevant articles and documents

Benzylic aroylation of toluenes with unactivated tertiary benzamides promoted by directed ortho-lithiation

The deprotonative functionalization of toluenes, for their weak acidity, generally needs strong bases, thus leading to the requirement of harsh conditions and the generation of by-products. Direct nucleophilic acyl substitution reaction of amides with organometallic reagents could provide an ideal solution for ketone synthesis. However, the inert amides and highly reactive organometallic reagents bring great challenges for an efficient and selective synthetic approach. Herein, we reported an lithium diisopropylamide (LDA)-promoted benzylic aroylation of toluenes with unactivated tertiary benzamides, providing a direct and efficient synthesis of various aryl benzyl ketones. This process features a kinetic deprotonative functionalization of toluenes with a readily available base LDA. Mechanism studies revealed that the directed ortho-lithiation of the tertiary benzamide with LDA promoted the benzylic kinetic deprotonation of toluene and triggered the nucleophilic acyl substitution reaction with the amide. [Figure not available: see fulltext.].