63237-87-6

Basic information

• Product Name: PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID
• Synonyms: PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID;Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid 97%
• CAS NO: 63237-87-6
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.15
• Mol File: 63237-87-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 218-218.5
• Appearance: /
• Density: 1.64 g/cm³
• Refractive Index: 1.718
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID(63237-87-6)
• EPA Substance Registry System: PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID(63237-87-6)

Safety Data

• Hazardous Substances Data: 63237-87-6(Hazardous Substances Data)

Usage

General Description

PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID is a chemical compound with the molecular formula C9H5N3O4. It is a heterocyclic compound containing a pyrazole ring fused to a pyridine ring with two carboxylic acid groups attached. PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID has potential pharmaceutical applications and is being studied for its potential as an anti-inflammatory and analgesic agent. It is also being investigated for its potential use in the treatment of neurodegenerative diseases. Additionally, PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLIC ACID is used in the field of organic synthesis and medicinal chemistry for the development of new drugs and pharmaceuticals.

InChI:InChI=1/C9H6N2O4/c12-8(13)6-5-3-1-2-4-11(5)10-7(6)9(14)15/h1-4H,(H,12,13)(H,14,15)

Upstream product

• 25275-41-6 N-iminopyridinium ylide 
• 110-86-1 pyridine 
• 5825-71-8 pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester 

Downstream Products

• 885275-10-5 pyrazolo[1,5-a]pyridine-2-carbaldehyde 
• 76943-47-0 pyrazolo[1,5-a]pyridin-2-ylmethanol 

Relevant articles and documents

Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions

The design of some novel di-(het)arylated-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidine derivatives is reported. The series was developed from 1-aminopyridinium iodide, which afforded the key intermediate bearing two thiomethyl and amide functions, each of them useful for palladium catalyzed cross coupling reactions by alkyl sulfur release and C-O activation, respectively. The two regioselective and successive cross-coupling reactions were first carried out in C-4 by in situ C-O activation and next in C-2 by a methylsulfur release. Process optimization furnished conditions leading to products in high yields. The scope and limitations of the methodologies were evaluated and the final compounds characterized.

1,3-Dipolar Addition of Pyridine N-Imine to Acetylenes and the Use of C-13 NMR in Several Structural Assignments

Addition of pyridine-N-imine to a variety of acetylenic mono- (Scheme I) and di- (Scheme II) carboxylic ester dipolarophiles was carried out.Several of the 3-azapyrrocoline esters obtained were further converted into acids, amides and hydrazides as shown in Schemes I and II.