63237-95-6Relevant articles and documents
Synthesis and biological evaluation of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones as topoisomerase I inhibitors
Luo, Laichun,Wang, Qiang,Xiang, Yuanhang,Peng, Xiaozhi,Hu, Chunling
, p. 1220 - 1229 (2022/02/01)
[Figure not available: see fulltext.] A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones were designed, synthesized, and evaluated as anticancer agents. Among them, two compounds demonstrated potent cytotoxicity and topoisomerase I inhibitory activity.