63238-04-0

Basic information

• Product Name: 4-amino-2-(methylsulfanyl)-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide
• CAS NO: 63238-04-0
• Molecular Formula: C₁₅H₁₃N₃OS₂
• Molecular Weight: 315.4132
• Mol File: 63238-04-0.mol
• Article Data: 2

Chemical Properties

• Density: 1.42g/cm³
• Refractive Index: 1.744
• CAS DataBase Reference: 4-amino-2-(methylsulfanyl)-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-2-(methylsulfanyl)-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide(63238-04-0)
• EPA Substance Registry System: 4-amino-2-(methylsulfanyl)-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide(63238-04-0)

Safety Data

• Hazardous Substances Data: 63238-04-0(Hazardous Substances Data)

Upstream product

• 22344-79-2 α-bromo-N-β-naphthylacetamide 
• 13145-41-0 potassium cyanocarbonimidodithioate 
• 74-88-4 methyl iodide 
• 91-59-8 naphthalen-2-ylamine 
• 5453-65-6 N-(2-naphthyl)-2-chloroacetamide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors

Pin1 is a peptidyl prolyl cis-trans isomerase (PPIase) and inhibiting Pin1 is a potential way for discovering anti-tumor agents. With an aim to find potent Pin1 inhibitors with a novel scaffold, a series of thiazole derivatives with an alicyclic heterocycles on the 2-position were designed, synthesized and tested against human Pin1. Compound 9p bearing a 2-oxa-6-azaspiro [3,3] heptane moiety on the thiazole scaffold was identified as the most potent Pin1 inhibitor of this series with an IC50 value of 0.95 μM. The structure-activity relationship (SAR) and molecular modeling study indicated that introducing an alicyclic ring with an H-bond acceptor would be a viable way to improve the binding affinity.