63239-84-9Relevant academic research and scientific papers
Aryldiazenyl Radicals from Arylazo Sulfones: Visible Light-Driven Diazenylation of Enol Silyl Ethers
Othman Abdulla, Havall,Scaringi, Simone,Amin, Ahmed A.,Mella, Mariella,Protti, Stefano,Fagnoni, Maurizio
, p. 2150 - 2154 (2020)
A versatile protocol for the diazenylation of enol silyl ethers under visible light irradiation is presented herein. The reaction is based on the underused reaction of a nitrogen-based radical (the diazenyl radical) with an enol silyl ether. Arylazo sulfones were used as photoactivatable precursors of these diazenyl radicals. The resulting azaderivatives are potentially bioactive compounds as well as starting materials for the synthesis of N-containing heterocycles. (Figure presented.).
Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF-7 cells
Ismail, Magda M. F.,Soliman, Dalia H.,Sabour, Rehab,Farrag, Amel M.
, (2020/09/18)
New 4-arylazo-3,5-diamino-1H-pyrazole derivatives substituted in the 4-aryl ring with the acetyl moiety were designed and synthesized. The antiproliferative activity of the novel arylazopyrazoles was examined against the MCF-7 cell line. Among all target compounds, 8b (IC50 3.0 μM) and 8f (IC50 4.0 μM) displayed higher cytotoxicity as compared with the reference standard imatinib (IC50 7.0 μM). Further studies to explore the mechanism of action were performed on the most active hit of our library, 8b, via anti-CDK2 kinase activity. It demonstrated good inhibitory effects for CDK2 (IC50 0.24 μM) with 62.5% inhibition, compared with imatinib. The cell cycle analysis in the MCF-7 cell line revealed apoptosis induction by 8b and cell cycle arrest at the S phase. Docking in the CDK2 active site and pharmacophore modeling confirmed the affinity of 8b to the CDK2 active site. Absorption, distribution, metabolism, and excretion studies revealed that our target compounds are orally bioavailable, with no permeation through the blood–brain barrier.
3-(para-Substituted phenylhydrazo)pentane-2,4-diones: Physicochemical and solvatochromic properties
Mahmudov, Kamran T.,Maharramov, Abel M.,Aliyeva, Rafiga A.,Aliyev, Ismayil A.,Askerov, Rizvan K.,Batmaz, Rasim,Kopylovich, Maximilian N.,Pombeiro, Armando J.L.
experimental part, p. 159 - 165 (2012/01/14)
New azoderivatives of pentane-2,4-dione, 3-(4-bromophenylhydrazo)pentane-2, 4-dione (HL1) and 3-(4-acetylphenylhydrazo)pentane-2,4-dione (HL 2), have been synthesized by reaction between pentane-2,4-dione and the corresponding aryldi
