6326-86-9

Basic information

• Product Name: methyl 2,5,5-trimethyl-4,5-dihydro-1,3-thiazole-4-carboxylate
• CAS NO: 6326-86-9
• Molecular Formula: C₈H₁₃NO₂S
• Molecular Weight: 187.2593
• Mol File: 6326-86-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 231.4°C at 760 mmHg
• Flash Point: 93.7°C
• Density: 1.18g/cm³
• Vapor Pressure: 0.0625mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: methyl 2,5,5-trimethyl-4,5-dihydro-1,3-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,5,5-trimethyl-4,5-dihydro-1,3-thiazole-4-carboxylate(6326-86-9)
• EPA Substance Registry System: methyl 2,5,5-trimethyl-4,5-dihydro-1,3-thiazole-4-carboxylate(6326-86-9)

Safety Data

• Hazardous Substances Data: 6326-86-9(Hazardous Substances Data)

Upstream product

• 2208-07-3 ethyl acetimidate hydrochloride 
• 34297-27-3 D-penicillamine methyl ester hydrochloride 
• 7647-01-0 hydrogenchloride 
• 59-53-0 NAP 
• 186581-53-3 diazomethane 
• 39239-88-8 methyl 2-acetamido-3-methylbut-2-enoate 

Relevant articles and documents

Synthesis and Nuclear Magnetic Resonance Study of 2-Thiazolines

A series of 5,5-dimethyl-2-thiazoline-4-carboxylates with a phenyl or methyl group at the 2-position of the ring were prepared from the corresponding methyl or ethyl ester of penicillamine and either methyl benzimidate or ethyl acetimidate.The free acid was obtained by the reaction of penicillamine with benzonitrile to produce 5,5-dimethyl-2-phenyl-2-thiazoline-4-carboxylic acid.Corresponding thiazolines were prepared from cysteine in the same manner.The nuclear magnetic resonance spectra of both series exhibit coupling of the methyl group at the 2-position with the hydrogen at the 4-position.The groups at the 5-position are nonequivalent and in the case of the cysteine series give rise to an ABX system.Further analysis confirms a concentration dependence for this splitting pattern.