85098-64-2

Basic information

• Product Name: 4-Anilino-1-benzyl-4-piperidinecarboxylic acid
• Synonyms: 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid;4-(Phenylamino]-1-benzyl-4-piperidinecarboxylic Acid;4-Anilino-1-benzylpiperidine-4-carboxylic Acid;NSC 73748;4-Piperidinecarboxylicacid,4-(phenylamino)-1-(phenylmethyl)-;1-BENZYL-4-PHENYLAMINO-4-CARBOXY-PIPERIDINE;1-Benzyl-4-anilinopiperidine-4-carboxylic acid;4-(Phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylic acid
• CAS NO: 85098-64-2
• Molecular Formula: C₁₉H₂₂N₂O₂
• Molecular Weight: 310.39018
• EINECS: 285-415-7
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 85098-64-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 495.6 °C at 760 mmHg
• Flash Point: 253.5 °C
• Appearance: Grey Solid
• Density: 1.234 g/cm³
• Vapor Pressure: 1.22E-10mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: 4-Anilino-1-benzyl-4-piperidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Anilino-1-benzyl-4-piperidinecarboxylic acid(85098-64-2)
• EPA Substance Registry System: 4-Anilino-1-benzyl-4-piperidinecarboxylic acid(85098-64-2)

Safety Data

• Hazardous Substances Data: 85098-64-2(Hazardous Substances Data)

Usage

Chemical Properties

Grey Solid

Uses

Different sources of media describe the Uses of 85098-64-2 differently. You can refer to the following data:
1. A piperidine derivative as potential analgesic agent
2. A piperidine derivative as potential analgesic agent.

InChI:InChI=1/C19H22N2O2/c22-18(23)19(20-17-9-5-2-6-10-17)11-13-21(14-12-19)15-16-7-3-1-4-8-16/h1-10,20H,11-15H2,(H,22,23)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 67-66-3 chloroform 
• 62-53-3 aniline 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 

Downstream Products

• 63260-82-2 ethyl 1-benzyl-4-phenylamino-4-piperidinecarboxylate 
• 61086-04-2 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol 
• 61085-60-7 methyl 4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylate 
• 61085-72-1 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-1-benzyl-4-piperidinecarboxylate 
• 72996-78-2 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate 
• 61380-02-7 4-(methoxymethyl)-N-phenyl-1-(phenylmethyl)-4-piperidinamine 
• 1217504-89-6 C₁₉H₂₂⁽²⁾H₂N₂O 
• 130819-95-3 1'-benzyl-3-phenylspiro<4,5-dihydro-3H-1,2,3-oxathiazol-4,4'-piperidine> 
• 130819-96-4 4-(anilinomethyl)-1-benzyl-4-chloropiperidine 

Relevant articles and documents

SUBSTITUTED N-(2-(AMINO)-2-OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES

The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

A facile method for preparation of [2H3]-sufentanil and its metabolites

An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.

MUSCARINIC MODULATORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.