632625-43-5Relevant articles and documents
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists
Hall, Adrian,Atkinson, Stephen,Brown, Susan H.,Chessell, Iain P.,Chowdhury, Anita,Giblin, Gerard M.P.,Goldsmith, Paul,Healy, Mark P.,Jandu, Karamjit S.,Johnson, Matthew R.,Michel, Anton D.,Naylor, Alan,Sweeting, Jennifer A.
, p. 1200 - 1205 (2007/10/03)
Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high bi
PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES
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, (2010/02/05)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine, in particular their use in the treatment of prostaglandin mediated diseases such as pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.