63277-46-3Relevant academic research and scientific papers
INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE
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Page/Page column 40; 41, (2020/05/21)
A compound of formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: Formula I wherein X1 is benzimidazolyl, substituted benzimidazolyl, azabenzimidazolyl, substituted azabenzimidazolyl, pyrazolyl, or substituted pyrazolyl; X2 is aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, substituted (cycloalkyl)alkyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, alkyl, substituted alkyl, alkoxycarbonyl, substituted alkoxycarbonyl, dialkylaminocarbonyl, substituted dialkylaminocarbonyl, (heterocycloalkyl)carbonyl, or substituted (heterocycloalkyl)carbonyl; X3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, or substituted (cycloalkyl)alkyl; and X4 is hydroxy, amino, alkyl, or hydrogen.
FUSED HETEROCYCLIC COMPOUNDS
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Page/Page column 157, (2012/02/15)
The present invention provides a compound which has the effect of PDE 10A inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound represented by the formula (1'): wherein, Ring A' represents an optiona
An alternative total synthesis of pentosidine
Liu, Yahua,Zhang, Weihan,Sayre, Lawrence M.
experimental part, p. 426 - 433 (2011/06/22)
Pentosidine, a fluorescent advanced glycation endproduct that serves as a biomarker of diabetic complications, kidney dysfunction, oxidative stress, and aging and age-related diseases, was synthesized from 2,3-diaminopyridine and benzyloxycarbonyl (Cbz) p
FUSED HETEROCYCLIC COMPOUNDS
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, (2012/01/13)
The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia. The compound is represented by the formula (I): wherein the symbols are defined in the specification.
A straightforward synthesis of pentosidine framework
Liu, Yahua,Zhang, Weihan,Sayre, Lawrence M.
experimental part, p. 683 - 686 (2010/08/22)
This work was performed under Professor Sayre's direction. Professor Lawrence M. Sayre passed away May 8, 2009, following an incapacitating stroke. His impact on the lives of his colleagues, students, and friends was profound and he is deeply missed [3]. We dedicate this article to him as a great mentor and brilliant scientist. (Chemical Equation Presented) Pentosidine framework 4-butyl-2-propyl-4H-aminoimidazo[4,5-b]pyridine (2) was synthesized through a five steps reaction sequence. The regiochemistry of 2 was confirmed by an unambiguous synthesis, and the UV absorption and fluorescent properties of 2 were examined.
