63283-56-7

Usage

Uses

Used in Pharmaceutical Synthesis:
(4'-Methylbiphenyl-4-yl)(phenyl)methanone is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs and medicinal compounds. Its unique structure allows for the creation of a wide range of organic compounds with potential therapeutic applications.
Used in Specialty Chemical Production:
(4'-Methylbiphenyl-4-yl)(phenyl)methanone serves as a precursor in the production of specialty chemicals, including dyes and other complex organic molecules. Its role in this process is crucial for the synthesis of high-quality and specialized chemical products.
Used in Material Science:
(4'-Methylbiphenyl-4-yl)(phenyl)methanone has potential applications in the field of material science, where it can be employed to develop new materials with specific properties. Its chemical characteristics make it suitable for use in the creation of innovative materials for various industries.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, (4'-Methylbiphenyl-4-yl)(phenyl)methanone plays a significant role in the formation of coordination compounds. Its ability to bind with metal ions allows for the development of new complexes with unique properties and potential applications in various fields.

Upstream product

• 644-08-6 4-Methylbiphenyl 
• 98-88-4 benzoyl chloride 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 5720-05-8 4-methylphenylboronic acid 
• 83887-62-1 4-benzoylphenyl methane sulfonate 
• 530-44-9 4-(Dimethylamino)benzophenone 
• 31688-74-1 p-PhC(O)C₆H₄NMe₃(+)*I(-) 
• 90252-89-4 p-tolylzinc(II) chloride 
• 134-85-0 4-chlorobenzophenone 
• 345-83-5 4-fluorobenzophenone 
• 2128-93-0 biphenyl-4-yl-phenyl-methanone 
• 5158-46-3 methylzinc chloride 
• 106-38-7 para-bromotoluene 
• 1137-42-4 4-Hydroxybenzophenone 

Downstream Products

• 1402905-62-7 C₂₆H₂₀ClN 
• 1402905-42-3 C₂₆H₁₉N 
• 1402905-43-4 C₂₆H₁₉N 
• 1402905-44-5 6-(4'-methyl-[1,1'-biphenyl]-4-yl)phenanthridine 
• 140621-36-9 4'-(bromomethyl)-4-biphenylyl phenyl ketone 
• 63242-37-5 4-(Chloro-phenyl-methyl)-4'-methyl-biphenyl 
• 63242-25-1 diphenyl-4-tolylcarbinol 

Relevant academic research and scientific papers

Aldehydes and ketones influence reactivity and selectivity in nickel-catalysed Suzuki-Miyaura reactions

The energetically-favorable coordination of aldehydes and ketones-but not esters or amides-to Ni0 during Suzuki-Miyaura reactions can lead either to exquisite selectivity and enhanced reactivity, or to inhibition of the reaction. Aryl halides w

Nickel versus Palladium in Cross-Coupling Catalysis: On the Role of Substrate Coordination to Zerovalent Metal Complexes

A detailed comparison of the effect of coordinating functional groups on the performance of Suzuki-Miyaura reactions catalysed by nickel and palladium is reported, using competition experiments, robustness screening, and density functional theory calculations. Nickel can interact with a variety of functional groups, which manifests as selectivity in competitive cross-coupling reactions. The presence of these functional groups on exogenous additives has effects on cross-coupling reactions that range from a slight improvement in yield to the complete cessation of the reaction. In contrast, palladium does not interact sufficiently strongly with these functional groups to induce selectivity in cross-coupling reactions; the selectivity of palladium-catalysed cross-coupling reactions is predominantly governed by aryl halide electronic properties.

A Highly Efficient Monophosphine Ligand for Parts per Million Levels Pd-Catalyzed Suzuki–Miyaura Coupling of (Hetero)Aryl Chlorides

A new indolylphosphine WK-phos has been synthesized for Pd-catalyzed Suzuki–Miyaura coupling of (hetero)aryl chlorides with (alkyl)arylboronic acids. Comprising this newly developed ligand with palladium(II) acetate, the resulting catalyst system was found to be highly effective in facilitating the reaction even when the catalyst loading reaches parts per million levels (e.g. 10 ppm). These examples represent one of the lowest catalyst loadings reported to date of employing monophosphine (e.g. Ar-PCy2) for Suzuki–Miyaura reactions. The ligand geometry has also been well-characterized by single-crystal X-ray crystallography.

Selective Methylation of Arenes: A Radical C?H Functionalization/Cross-Coupling Sequence

A selective, nonchelation-assisted methylation of arenes has been developed. The overall transformation, which combines a C?H functionalization reaction with a nickel-catalyzed cross-coupling, offers rapid access to methylated arenes with high para selectivity. The reaction is amenable to late-stage methylation of small-molecule pharmaceuticals.

Highly bulky and stable geometry-constrained iminopyridines: Synthesis, structure and application in Pd-catalyzed Suzuki coupling of aryl chlorides

A series of bulky geometry-constrained iminopyridylpalladium chlorides were developed. The steric environment adjacent to the nitrogen atom in the pyridine rings and diimine parts enhanced the thermal stability of the palladium species. Bulkier groups at the imino group stabilized the palladium species and the corresponding palladium chlorides showed high activities in the coupling reaction of aryl chlorides.

Phosphine ligand for indole skeleton as well as preparation method and application of phosphine ligand

The invention provides a phosphine ligand for a 3-(disubstituted phosphino)-1-alkyl-2-substituted phenyl-indole skeleton as well as a preparation method and application of the phosphine ligand. The structure of the phosphine ligand for the 3-(disubstituted phosphino)-1-alkyl-2-substituted phenyl-indole skeleton is shown as the following formula I: (shown in the description), wherein Z is carbon or nitrogen, R is alkyl, substituted alkyl, olefin, aryl or fluorine, R1 is alkyl, substituted alkyl or aryl, R2 is alkyl, substituted alkyl or fluorine, and R3 is alkyl, substituted alkyl or aryl.

Ligand-free Pd catalyzed cross-coupling reactions in an aqueous hydrotropic medium

A simple, efficient and ligand-free protocol for the Suzuki-Miyaura reaction and base-free Heck-Matsuda reactions under mild reaction conditions have been developed over palladium supported on activated carbon (Pd/C) in an aqueous hydrotropic solution. The catalyst Pd/C was fully characterized by TG-DTA, SEM, EDS, XRD, XPS, BET and ICP-AES analyses. This green methodology represents a cost-effective and operationally convenient method for the synthesis of a variety of biaryls, prochiral ketones, and acrylates under the conditions that are tolerant for a broad range of functional groups with good to excellent yields. The developed Pd/C-aqueous hydrotrope combined catalytic system is well suited for the 3R approach (reducible, robust, and recyclable) for different cross-coupling reactions without an appreciable loss of its activity.

The Barbier-Grignard-Type Arylation of Ketones and Unexpected Cross-Coupling of Phenolic Ketones using Unactivated Aryl Bromides

A novel, highly versatile and efficient method has been developed for the Barbier-Grignard-type arylation of ketones and an unexpected cross-coupling of phenolic ketones was observed using unactivated bromides and magnesium in tetrahydrofuran/toluene at 96°C promoted by multicatalysts of cupric bromide (15 mol%), bismuth chloride (5 mol%) and silver bromide (10 mol%). The substituent and electronic effects on the reaction have been discussed. High yields of arylation and cross-coupling have been attained under mild conditions. A novel reasonable mechanism involving a quinone intermediate is proposed. The high chemical selectivity in the cross-coupling to the hydroxy group of phenolic ketones should help ketones find new applications.

Pincer-Nickel-Catalyzed Cross-Coupling of Aryl Sulfamates with Arylzinc Chlorides

The nickel N,N,N-pincer complex 2 was demonstrated to effectively catalyze the cross-coupling of aryl sulfamates with arylzinc chlorides under mild conditions. The reaction is suitable for a wide range of substrates, and tolerates various functional groups. A nickel N,N,N-pincer complex effectively catalyzes the cross-coupling of aryl sulfamates with arylzinc chlorides under mild conditions. The reaction is suitable for a wide range of substrates, and tolerates various functional groups.

P,N,N-Pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

P,N,N-Pincer nickel complexes [Ni(Cl){N(2-R2PC6H 4)(2′-Me2NC6H4)}] (R = Ph, 3a; R = Pri, 3b; R = Cy, 3c) were synthesized and their catalysis toward the Kumada or Negishi cross-coupling reaction of aryl fluorides and chlorides was evaluated. Complex 3a effectively catalyzes the cross-coupling of (hetero)aryl fluorides with aryl Grignard reagents at room temperature. Complex 3a also catalyzes the cross-coupling of (hetero)aryl chlorides and arylzinc reagents at 80 °C with low catalyst loadings and good functional group compatibility. the Partner Organisations 2014.