63286-28-2

Basic information

• Product Name: 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE
• Synonyms: 2-CHLORO-3-HYDRAZINYLPYRAZINE;3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE;(3-Chloropyrazin-2-yl)hydrazine;2-Chloro-3-hydrazinopyrazine;2-chloro-3-hydrazinopyrazine(SALTDATA: FREE);2-(3-chloropyrazin-2-yl)hydrazine;Pyrazine,2-chloro-3-hydrazinyl-;(3-Chloro-pyrazin-2-yl)-hydrazine hydrochloride
• CAS NO: 63286-28-2
• Molecular Formula: C₄H₅ClN₄
• Molecular Weight: 183.04
• Mol File: 63286-28-2.mol
• Article Data: 28

Chemical Properties

• Melting Point: 154-159°C
• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.53 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.27±0.20(Predicted)
• CAS DataBase Reference: 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE(63286-28-2)
• EPA Substance Registry System: 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE(63286-28-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 63286-28-2(Hazardous Substances Data)

Usage

General Description

3-Chloro-2-hydrazino-1,2-dihydropyrazine hydrochloride is a chemical compound with the molecular formula C4H8ClN3. It is a hydrazine derivative with a chlorine atom attached to the 3-position and a hydrazino group attached to the 2-position of the dihydropyrazine ring. 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. It has also been studied for its potential antitumor and antitubercular activities. 3-Chloro-2-hydrazino-1,2-dihydropyrazine hydrochloride is a white to off-white crystalline solid that is typically stored and handled as a dry powder or solid material.

InChI:InChI=1/C4H7ClN4.ClH/c5-3-4(9-6)8-2-1-7-3;/h1-2,4,8-9H,6H2;1H

Upstream product

• 7461-50-9 2-chloropyrimidin-4-amine 
• 4858-85-9 2,3-dichloropyrazine 

Downstream Products

• 68797-02-4 3-benzyl-8-chloro-[1,2,4]triazolo[4,3-a]pyrazine 
• 167694-38-4 8-Chloro-3-(3-fluoro-benzyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 167694-39-5 8-Chloro-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 167694-37-3 8-chloro-3-(2-fluorobenzyl)-1,2,4-triazolo<4,3-a>pyrazine 
• 167694-40-8 8-Chloro-3-(2,5-difluoro-benzyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 167694-41-9 8-Chloro-3-(2,6-difluoro-benzyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 140910-77-6 8-chloro-3-ethyl[1,2,4]triazolo[4,3-a]piperazine 
• 68774-77-6 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine 
• 68774-78-7 8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine 
• 98792-24-6 3-phenylamino-1H-pyrazino<2,3-e>-1,3,4-thiadiazine 
• 140910-71-0 8-chloro-3-phenyl-[1.2.4]triazolo[4,3-a]pyrazine 
• 77888-19-8 8-chlorotetrazolo[1,5-a]pyrazine 
• 1073488-33-1 2-(4-chlorophenyl)-N'-(3-chloropyrazine-2-yl)-2-methylpropanehydrazide 
• 1073488-43-3 1-(4-chlorophenyl)-N'-(3-chloropyrazine-2-yl)cyclopropanecarbohydrazide 

Relevant articles and documents

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3- a]pyrazine-Based Antimalarials

We have discovered and studied a tele-substitution reaction in a biologically important heterocyclic ring system. Conditions that favor the tele-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base or the use of softer nucleophiles, less polar solvents, and larger halogens on the electrophile. Using results from X-ray crystallographic and isotope labeling experiments, a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the in vivo active antiplasmodium compounds of Series 4 of the Open Source Malaria consortium.

An original class of small sized molecules as versatile fluorescent probes for cellular imaging

An unusual class, compact in size, of fluorescent probes based on pyridazino-1,3a,6a-triazapentalene scaffolds exhibits promising fluorescent properties (quantum yield values up to 73%, large Stokes shifts, emission wavelengths located in the green-yellow