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Usage

Uses

Used in Polymer Production Industry:
Monomethacrylamideethylenediamine is used as a monomer for the synthesis of polymers, contributing to the material's properties such as hardness, flexibility, and durability. Its reactivity in free radical polymerization makes it a valuable component in the production of resins, lacquers, adhesives, and plastic materials.
Used in Material Modification:
Monomethacrylamideethylenediamine is used as a modifier to enhance the properties of existing materials. Its ability to participate in free radical polymerization allows it to improve the performance of materials in various applications, such as increasing their resistance to wear and tear or improving their overall strength.

Upstream product

• 38862-25-8 methacrylic acid N-hydroxysuccinimide ester 
• 107-15-3 ethylenediamine 
• 920-46-7 Methacryloyl chloride 
• 206554-56-5 <<(2-methyl-1-oxo-2-propenyl)amino>ethyl>-carbamic acid tert-butylester 

Downstream Products

• 202207-83-8 N-methyl, N'-methacryloyl-ethylenediamine monohydrochloride 

Relevant academic research and scientific papers

Characteristics of an RNA Diels-Alderase active site

The active site components and substrate specificity of an RNA Diels- Alderase (DA22) were investigated. Diels-Alderase activity was found to be highly dependent on a unique 5-position pyridyl modified uridine. Even closely related pyridyl modifications failed to yield active catalysts. Substrate specificity of this Diels-Alderase was remarkable. Experiments with alternative diene and dienophile substrates showed the active site of the Diels-Alderase to be highly discriminating, even against molecules of similar reactivity and structure. Inhibition studies with a series of product analogues established that the RNA recognizes functional components in and around the reaction center of both the diene and the dienophile. Taken together, these results suggest that DA22 can fold into a structure that produces an intricate metal/ligand dependent active site capable of highly specific molecular recognition.

Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery

The affinity of a synthetic polymer nanoparticle (NP) to a target biomacromolecule is determined by the association and dissociation rate constants (kon, koff) of the interaction. The individual rates and their sensitivity to local environmental influences are important factors for the on-demand capture and release a target biomacromolecule. Positively charged NPs for small interfering RNA (siRNA) delivery is a case in point. The knockdown efficacy of siRNA can be strongly influenced by the binding kinetics to the NP. Here, we show that kon and koff of siRNA to NPs can be individually engineered by tuning the chemical structure and composition of the NP. N-Isopropylacrylamide-based NPs functionalized with hydrophobic and amine monomers were used. koff decreased by increasing the amount of amine groups in the NP, whereas kon did not change. Importantly, NPs showing a low koff at pH 5.5 together with a high koff at pH 7.4 showed high knockdown efficiency when NP/siRNA complexes were packaged in lipid nanoparticles. These results provide direct evidence for the premise that the efficacy of an siRNA delivery vector is linked with the strong affinity to the siRNA in the endosome and low affinity in the cytoplasm.

Electrophoresis gels and cross-linking agents for their preparation

Method of separating molecules by providing a cross-linked polymer gel having a cross-linking moiety of the formula wherein X, X′, Y, Z and R2 are as defined in the specification. A sample containing the molecules to be separated is placed on the gel, and the gel is subjected to a separation technique.

Propenamide derivatives containing Arg-Gly-Asp polymers obtained therefrom

A propenamide derivative of the formula (I) having, as an essential structural unit, an adhesive peptide represented by the formula (II) in the side chain or salts thereof: Formula (I): R1R2C=CR3-CO-[NH]-Formula (II): -[R4]-[CO]-([X]-Arg-Gly-Asp-[Y])n-[Z]-[R5]-wherein R1 and R2 each represents a hydrogen atom or a carboxyl group and R3 represents a hydrogen or halogen atom, methyl, ethyl or carboxymethyl group; X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue consisting of two or more of the amino acids; z represents -O- or -NH-; one of R4 and R5 represents a hydrogen atom, and the other represents a linear or branched alkylene group having 1 to 11 carbon atoms or an arylene group having 6 to 11 carbon atoms wherein the alkylene and arylene groups may be substituted with one or more halogen atom, carbonyl, carboxyl, amino, hydroxyl, sulfo, aryl, nitro or cyano group, or unsaturated double or triple bond; n is an integer of from 1 to 5; and [ ] means that each corresponding group or residue therebetween may be present or absent. A copolymer and crosslinked copolymer of the derivative with an anionic or cationic monomer or additional polyfunctional polymer. The use of the compounds for inhibiting adhesion of animal cells, or coagulation.adhesion of blood platelets, or for cultivating animal cells.