63314-58-9

Usage

Uses

Used in Medicinal Chemistry:
4-(4-METHYLPHENYL)-5-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL is used as a potential candidate in medicinal chemistry for its possible biological activity and structural features, making it a promising compound for drug discovery and development.

InChI:InChI=1/C15H13N3S/c1-11-7-9-13(10-8-11)18-14(16-17-15(18)19)12-5-3-2-4-6-12/h2-10H,1H3,(H,17,19)

Upstream product

• 38240-76-5 4-(4-methylphenyl)-1-benzoyl-thiosemicarbazide 
• 613-94-5 benzoic acid hydrazide 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 100-52-7 benzaldehyde 
• 13278-67-6 4-(4-methylphenyl)-3-thiosemicarbazide 

Downstream Products

• 14331-67-0 4-(4-methylphenyl)-3-phenyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis of 1,2,4-Triazoles via Oxidative Heterocyclization: Selective C-N Bond over C-S Bond Formation

The higher propensity of C-N over C-S bond forming ability was demonstrated, through formal C-H functionalization during the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides catalyzed by Cu(II). However, ster

Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

Photochemical synthesis of triazolo[3,4-b]-1,3(4H)-benzothiazines: A detailed mechanistic study on photocyclization/photodesulfurisation of triazole-3-thiones

Irradiation of 4-(2-halobenzyl)-5-substituted-1,2,4-triazole-3-thiones under base mediated (CH3CN/2 M NaOH) condition afforded triazolo[3,4-b]-1,3(4H)-benzothiazines and desulfurized triazoles. Benzophenone sensitized photolysis of triazole-3-thiones gave desulfurized triazoles exclusively. The mechanism of the photocyclization/photodesulfurization and the involvement of singlet and triplet energy levels are discussed.

Photodesulfurization of 2,4-diaryl-1,2, 4-triazole-3-thiones

The photodesulfurization of 2,4-diaryl-1,2,4-triazole-3-thiones was discussed in the article. The triazole thiones were synthesized from the respective acid hydrazide and isothiocyanate. The structure of the compounds were confirmed by spectral and analytical data. It was concluded that thioenolization may facilitate the desulfurization.