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Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 123-54-6 acetylacetone 
• 1118-66-7 4-Aminopent-3-en-2-one 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 1118-66-7 4-amino-3-penten-2-one 
• 100-58-3 phenylmagnesium bromide 
• 231609-68-0 N-methoxy-N-methyl-2-(1-methyl-3-oxo-1-butenylamino)propionamide 
• 109703-65-3 3-(4-Acetyl-2,3-dihydro-2,5-dimethyl-3-phenyl-2-furylimino)-2,4-pentandion 

Relevant academic research and scientific papers

Synthesis of tetrasubstituted NH pyrroles and polysubstituted furans via an addition and cyclization strategy

The FeCl3-catalyzed addition and cyclization of enamino esters with nitroolefins provides a straightforward and general method for the synthesis of tetrasubstituted NH pyrroles. This novel method tolerates a wide range of functionality, and allows for rapid elaboration of the nitroolefins into a variety of substituted pyrroles in good yields. Further, an efficient KOAc-promoted addition and cyclization protocol toward substituted furans has been described as well. Georg Thieme Verlag Stuttgart · New York.

One-pot three-component synthesis of tetrasubstituted N - H pyrroles from secondary propargylic alcohols, 1,3-dicarbonyl compounds and tert-butyl carbamate

(Chemical Equation Presented) Several tetrasubstituted N - H pyrroles, functionalized with ester or ketone groups at C-3 position, were prepared by one-pot coupling of secondary propargylic alcohols with 1,3-dicarbonyl compounds and tert-butyl carbamate,

Versatility of Weinreb amides in the Knorr pyrrole synthesis

N-Methoxy-N-methyl-α-enaminocarboxamides were prepared starting from enamines and Weinreb α-aminoamides. Their reaction with oganometallic compounds and subsequent cyclization constitute a versatile alternative in the Knorr pyrrole synthesis.

Heterocyclen aus α-Nitroolefinen. XII. 3-Acetyl-4,5-dihydro-5-(methyleneamino)furane und 3-Acylpyrrole aus α-Nitroolefinen und β-Diketonen

From α-nitroolefines 1 and β-diketones 2 3-acetyl-4,5-dihydro-5-(methyleneamino)furans 5 are prepared.Furans 5 react in acid medium to yield 1-unsubstituted 3-acylpyrroles 6, catalytic hydrogenation yields 1-substituted 3-acylpyroles 9.The (1)H-nmr and (13)C-nmr investigation prove the constitutions.