705-60-2

Basic information

• Product Name: 1-Phenyl-2-nitropropene
• Synonyms: (2-Nitro-1-propenyl)benzene;(2-Nitropropenyl)benzene;[(1E)-2-Nitro-1-propenyl]benzene;1-(2-nitropropenyl)-benzen;1-(2-Nitropropenyl)benzene;1-Phenyl-2-nitro-1-propene;1-Phenyl-2-nitro-propylen-(1,2);2-Nitro-1-phenyl-1-propene
• CAS NO: 705-60-2
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 1533716-785-6
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Acyclic;Alkenes;Organic Building Blocks;Building Blocks;Chemical Synthesis;Organic Building Blocks;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 705-60-2.mol
• Article Data: 92

Chemical Properties

• Melting Point: 63-65 °C(lit.)
• Boiling Point: 263 °C at 760 mmHg
• Flash Point: 115.7 °C
• Appearance: Yellow/Crystalline Powder
• Density: 1.141 g/cm³
• Vapor Pressure: 0.0172mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• Solubility: Acetone, Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: 1-Phenyl-2-nitropropene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-nitropropene(705-60-2)
• EPA Substance Registry System: 1-Phenyl-2-nitropropene(705-60-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• RTECS: DA6495000
• Hazardous Substances Data: 705-60-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow crystalline powder

Uses

1-phenyl-2-nitropropene is used in the production of pharmaceuticals, for instance, for drug Adderall, a drug used to treat ADHD and narcolepsy.

Application

(2-Nitropropenyl)benzene is a derivative of styrene (S687790), which exhibits herbicidal and antibacterial properties.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 8, 1950 DOI: 10.1021/jo01147a002Tetrahedron Letters, 26, p. 1193, 1985 DOI: 10.1016/S0040-4039(00)98431-4

General Description

trans-β-Methyl-β-nitrostyrene (1-phenyl-2-nitropropene), a nitrostyrene derivative is an α,β-disubstituted nitroalkene. It has been synthesized by reacting benzaldehyde with nitroethane and butylamine. Spectroscopic analysis of 1-phenyl-2-nitropropene has been done using FT-IR, FT-Raman, NMR and UV.

InChI:InChI=1/C9H9NO2/c1-8(10(11)12)7-9-5-3-2-4-6-9/h2-7H,1H3/b8-7+

Synthetic route

Nitroethane (79-24-3) + benzaldehyde (100-52-7) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With 3-(diethylamino)propyltrimethoxysilane supported on silica-alumina at 100℃; for 4h;	90%
With (2-hydroxyethyl)ammonium formate at 20℃; for 3h; Knoevenagel condensation; Ionic liquid;	90%
With aminopropylated nanosilica for 24h; Henry reaction; Reflux;	89%

1-phenyl-2-nitro-1-propanol acetate (66618-80-2) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With dmap In dichloromethane for 3h;	88%

Nitroethane (79-24-3) + benzylamine (100-46-9) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With 4-(4-fluorophenyl)naphthalene-1,2-dione; oxygen at 80℃; for 12h;	83%

2-methyl-3-phenyl-2-propenal (101-39-3) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With copper(II) nitrate trihydrate In water; acetonitrile at 130℃; for 12h;	39%

α-methylcinnamic acid (1199-77-5) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With diethyl ether; mixture of gaseous nitrogen oxides

Nitroethane (79-24-3) + benzaldehyde (100-52-7) → (2-nitroprop-1-enyl)benzene (705-60-2) + benzamide (55-21-0)

Conditions	Yield
With zinc(II) chloride at 130 - 140℃; im geschlossenen Rohr;

(1-Nitro-allyl)-benzene (62753-13-3) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With triethylamine

2-phenyl-1-nitroprop-1-ene (25236-39-9) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With triethylamine

(1,2-dibromo-2-nitro-propyl)-benzene (19419-13-7) + 2-lithio-2-nitropropane (147225-22-7) → 2-bromo-2-nitropropane (5447-97-2) + 2,3-dimethyl-2,3-dinitrobutane (3964-18-9) + (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
In dimethyl sulfoxide Ambient temperature;
In dimethyl sulfoxide for 0.166667h; Mechanism; Product distribution; Ambient temperature; also for other 1-aryl-1,2-dibromo-2-nitropropanes, also in the presence of p-dinitrobenzene or di-tert-butyl nitroxide;

Butyl-(2-nitro-1-phenyl-propyl)-amine (135711-45-4) → (2-nitroprop-1-enyl)benzene (705-60-2) + N-butylamine (109-73-9)

Conditions	Yield
In acetonitrile at 30℃; Equilibrium constant; other temp.;

2,3-dinitro-3-phenyl propane (90558-08-0) → (2-nitroprop-1-enyl)benzene (705-60-2) + (Z)-(2-nitroprop-2-en-1-yl)benzene (58321-79-2)

Conditions	Yield
With calcium oxide In cyclohexane for 0.75h; Title compound not separated from byproducts;

C15H15NO2S → (2-nitroprop-1-enyl)benzene (705-60-2) + thiophenol (108-98-5)

Conditions	Yield
In water; acetonitrile at 35℃; Equilibrium constant; Further Variations:; Temperatures;

1-phenylpropene (637-50-3) + 4.4'-dipropenyl-diphenyl → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: 15 percent / N2O4 / CCl4 / 120 h / Ambient temperature 2: aq. CaO / cyclohexane / 0.75 h View Scheme

2-nitro-1-phenylpropan-1-ol (26251-08-1, 26251-09-2, 38316-08-4, 38316-09-5, 6343-57-3) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: 58 percent / DMAP / diethyl ether / 1.5 h 2: 88 percent / DMAP / CH2Cl2 / 3 h View Scheme
With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere; Cooling with ice;

benzaldehyde (100-52-7) + aminoguanidine salt → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: 89 percent / t-BuOK * t-BuOH (1:1) / 2-methyl-propan-2-ol; tetrahydrofuran / 16 h / 0 °C 2: 58 percent / DMAP / diethyl ether / 1.5 h 3: 88 percent / DMAP / CH2Cl2 / 3 h View Scheme

Acetic acid 1-methyl-2-nitro-2-phenyl-ethyl ester (62634-68-8) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N 2: Et3N View Scheme
Multi-step reaction with 2 steps 1: Na2CO3 2: Et3N View Scheme

benzaldehyde (100-52-7) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / 16 h / 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice View Scheme

1-phenylpropene (637-50-3) → (2-nitroprop-1-enyl)benzene (705-60-2)

Conditions	Yield
With 1-butyl-3-methylimidazolium chloride; sodium nitrite at 80℃; for 1h; Schlenk technique; Sealed tube; Inert atmosphere;	52 %Chromat.

(2-nitroprop-1-enyl)benzene (705-60-2) → (Z)-(2-nitroprop-2-en-1-yl)benzene (58321-79-2)

Conditions	Yield
With polimer supported; triphenylphosphine In dichloromethane at 20℃; for 20h;	100%

(2-nitroprop-1-enyl)benzene (705-60-2) → (2-nitropropyl)benzene (17322-34-8)

Conditions	Yield
With formic acid; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; triethylamine; N-tosylethylenediamine In ethyl acetate at 28℃; for 0.5h; chemoselective reaction;	99%
With benzaldehyde; 1,2-diamino-benzene In butan-1-ol for 6h; Heating;	91%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; S-benzyl isothiouronium chloride In methanol at 60℃; Inert atmosphere;	90%

(2-nitroprop-1-enyl)benzene (705-60-2) + (ethoxycarbonylmethyl)dimethylsulfonium bromide (5187-82-6) → ethyl (4SR,5SR)-3-methyl-4-phenyl-4,5-dihydroisoxazole-5-carboxylate 2-oxide

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; stereoselective reaction;	98%

formaldehyd (50-00-0) + (2-nitroprop-1-enyl)benzene (705-60-2) + thiophenol (108-98-5) → 2-Methyl-2-nitro-3-phenyl-3-phenylsulfanyl-propan-1-ol (94421-45-1)

Conditions	Yield
With 1,1,3,3-tetramethylguanidine for 3h; Ambient temperature;	97%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-4-methyl-N-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0) → 2-[(2R,3S,4R)-1,2,3,4-tetrahydro-2-phenyl-3-methyl-3-nitro-1-(tosyl)-4-quinolinyl]-1-phenylethanone

Conditions

Yield

Stage #1: (2-nitroprop-1-enyl)benzene With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Stage #2: 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide In 1,2-dichloro-ethane; toluene at 20℃; for 12h; Reagent/catalyst; Solvent; enantioselective reaction;

96%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-1-(2-methoxyphenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one → 2-[(2R,3S,4R)-1,2,3,4-tetrahydro-2-phenyl-3-methyl-3-nitro-1-tosyl-4-quinolinyl]-1-(2-methoxyphenyl)ethanone

Conditions

Yield

Stage #1: (2-nitroprop-1-enyl)benzene With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Stage #2: (E)-1-(2-methoxyphenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one In 1,2-dichloro-ethane; toluene at 20℃; for 48h; enantioselective reaction;

96%

(2-nitroprop-1-enyl)benzene (705-60-2) + (6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetic acid ethyl ester (40129-54-2, 112342-27-5) → 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester (79823-24-8)

Conditions	Yield
In ethanol for 2h; Heating;	95%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-4-methyl-N-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0) → C31H28N2O5S

Conditions	Yield
Stage #1: (2-nitroprop-1-enyl)benzene With C32H28F6N4O3 In dichloromethane at 20℃; for 0.166667h; Stage #2: 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide In dichloromethane at 20℃; for 12h; Reagent/catalyst; enantioselective reaction;	95%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-4,4-dimethyl-1-(2-(tosylamino)phenyl)pent-1-en-3-one → 1-[(2R,3S,4R)-1,2,3,4-tetrahydro-2-phenyl-3-methyl-3-nitro-1-tosyl-4-quinolinyl]-3,3-dimethyl-2-butanone

Conditions	Yield
Stage #1: (2-nitroprop-1-enyl)benzene With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Stage #2: (E)-4,4-dimethyl-1-(2-(tosylamino)phenyl)pent-1-en-3-one In 1,2-dichloro-ethane; toluene at 20℃; for 24h; enantioselective reaction;	95%

(2-nitroprop-1-enyl)benzene (705-60-2) + β-naphthol (135-19-3) → 2-methyl-1-phenylnaphtho[2,1-b]furan (110973-39-2)

Conditions	Yield
With potassium carbonate In ethanol at 85℃; for 3h; Temperature; Solvent; Reagent/catalyst;	95%
With carbonaceous material (C-SO3H) In water at 60℃; for 10h; Green chemistry;	70%

(2-nitroprop-1-enyl)benzene (705-60-2) → 1-phenylpropan-2-one oxime (13213-36-0)

Conditions	Yield
With hydrogen In ethanol at 60℃; under 15001.5 Torr; for 0.333333h; Autoclave; chemoselective reaction;	94%
With sulfuric acid In water; isopropyl alcohol at 10 - 15℃; electrolysis;	91%
With sodium stannite In tetrahydrofuran; water for 0.416667h; Ambient temperature;	82%

(2-nitroprop-1-enyl)benzene (705-60-2) + isobutene (115-11-7) → 6,6-dimethyl-5,6-dihydro-3-methyl-4-phenyl-1,2-oxazine N-oxide (638133-04-7)

Conditions	Yield
With tin(IV) chloride In dichloromethane at -90℃;	94%
With tin(IV) chloride In dichloromethane at -94 - 30℃;
Diels-Alder Cycloaddition;

(2-nitroprop-1-enyl)benzene (705-60-2) → 5-methyl-4-phenyl-1H-1,2,3-triazole

Conditions	Yield
With sodium azide; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 60℃; for 1h;	94%
With sodium azide; benzoic acid at 80℃; for 0.416667h; Microwave irradiation;	57%

(2-nitroprop-1-enyl)benzene (705-60-2) → 4-methyl-5-phenyl-2H-1,2,3-triazole (80569-59-1)

Conditions	Yield
With sodium azide; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 60℃;	94%
With sodium azide; toluene-4-sulfonic acid at 80℃;

(2-nitroprop-1-enyl)benzene (705-60-2) + cyclopentene (142-29-0) → -(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-phenylcyclopent<1,2>oxazine N-oxide (142840-09-3)

Conditions	Yield
With tin(IV) chloride In dichloromethane at -78℃; for 0.75h; Product distribution; Mechanism; other nitroalkenes and cycloalkenes; diastereoselectivity; velocity;	93%
With tin(IV) chloride In dichloromethane at -78℃; for 0.75h;	93%
With tin(IV) chloride In dichloromethane at -94 - 30℃;

(2-nitroprop-1-enyl)benzene (705-60-2) + N-bromoacetamide (79-15-2) → 1-acetylamino-2-bromo-1-phenyl-2-nitropropane (1215288-71-3)

Conditions	Yield
With potassium phosphate In dichloromethane at 20℃; for 24h; Michael addition; regiospecific reaction;	92%

(2-nitroprop-1-enyl)benzene (705-60-2) + methyl 3-(benzylamino)but-2-enoate (72002-24-5, 36244-63-0) → methyl 1-benzyl-2,5-dimethyl-4-phenyl-1H-pyrrole-3-carboxylate (1320232-56-1)

Conditions	Yield
In methanol at 120℃; for 7h;	92%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-1-(4-chlorophenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one → 1-(4-chlorophenyl)-2-[(2R,3S,4R)-1,2,3,4-tetrahydro-2-phenyl-3-methyl-3-nitro-1-(tosyl)-4-quinolinyl]ethanone

Conditions

Yield

Stage #1: (2-nitroprop-1-enyl)benzene With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Stage #2: (E)-1-(4-chlorophenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one In 1,2-dichloro-ethane; toluene at 20℃; for 24h; enantioselective reaction;

92%

(2-nitroprop-1-enyl)benzene (705-60-2) + (E)-1-(4-bromophenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one → 1-(4-bromophenyl)-2-[(2R,3S,4R)-1,2,3,4-tetrahydro-2-phenyl-3-methyl-3-nitro-1-(tosyl)-4-quinolinyl]ethanone

Conditions

Yield

Stage #1: (2-nitroprop-1-enyl)benzene With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Stage #2: (E)-1-(4-bromophenyl)-3-(2-(tosylamino)phenyl)prop-2-en-1-one In 1,2-dichloro-ethane; toluene at 20℃; for 24h; enantioselective reaction;

92%

(2-nitroprop-1-enyl)benzene (705-60-2) + 1,3-cylohexanedione (504-02-9) + 2-methoxy-phenylamine (90-04-0) → 1-(2-methoxyphenyl)-2-methyl-3-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one (1519057-98-7)

Conditions	Yield
With L-proline In water at 60℃; for 10h; Green chemistry;	92%

(2-nitroprop-1-enyl)benzene (705-60-2) → (2S,3R)-(-)-2-methyl-2-nitro-3-phenyloxirane (22596-45-8, 39159-19-8, 61841-00-7, 68498-15-7, 87162-61-6, 134964-65-1)

Conditions	Yield
With sodium hypochlorite; C34H33N2O(1+)*Br(1-) In water; toluene at -20℃; Inert atmosphere; enantioselective reaction;	92%

2,2,2-trifluorodiazoethane (371-67-5) + (2-nitroprop-1-enyl)benzene (705-60-2) → 5-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazole

Conditions	Yield
With sodium phosphate; silver(l) oxide In tetrahydrofuran at 20℃; Schlenk technique; regioselective reaction;	92%

(2-nitroprop-1-enyl)benzene (705-60-2) → 2-amino-1-phenylpropane (60-15-1, 156-34-3, 51-64-9, 300-62-9)

Conditions	Yield
With sodium tetrahydroborate; borane-THF In tetrahydrofuran at 25℃; for 144h;	91%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether for 2h; Heating;	77%
With lithium aluminium tetrahydride In diethyl ether for 3h; Inert atmosphere; Reflux;	77%

(2-nitroprop-1-enyl)benzene (705-60-2) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → 1-benzyl-3-methyl-3-nitro-4-phenylpyrrolidine

Conditions	Yield
Stage #1: (2-nitroprop-1-enyl)benzene; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine In acetonitrile Heating; Modular flow reactor; Stage #2: With silica gel In acetonitrile Modular flow reactor;	91%

(2-nitroprop-1-enyl)benzene (705-60-2) + methyl 2-(5-bromo-3-formyl-1H-indol-2-yl)acetate → methyl 6-bromo-3-methyl-2-phenyl-9H-carbazole-1-carboxylate

Conditions	Yield
Stage #1: (2-nitroprop-1-enyl)benzene; methyl 2-(5-bromo-3-formyl-1H-indol-2-yl)acetate With 1,4-diaza-bicyclo[2.2.2]octane In water at 20℃; Green chemistry; Stage #2: With hydrogenchloride In water at 20℃; Green chemistry;	91%

ethanol (64-17-5) + (2-nitroprop-1-enyl)benzene (705-60-2) → 1-Ethoxy-1-phenyl-propan-2-one oxime (96301-73-4)

Conditions	Yield
With tin(ll) chloride for 0.333333h; Ambient temperature;	90%

(2-nitroprop-1-enyl)benzene (705-60-2) + ethanethiol (75-08-1) → 1-Ethylsulfanyl-1-phenyl-propan-2-one oxime (96301-74-5)

Conditions	Yield
With tin(ll) chloride for 0.333333h; Ambient temperature;	90%

(2-nitroprop-1-enyl)benzene (705-60-2) + Ethyl isocyanoacetate (2999-46-4) → ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (124901-12-8)

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; isopropyl alcohol at 10 - 20℃;	90%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Ambient temperature;	54%
With potassium carbonate In tetrahydrofuran at 20℃; for 16h;

(2-nitroprop-1-enyl)benzene (705-60-2) + quinazolin-3-ium-3-yl(tosyl)amide → 1-methyl-2-phenylpyrazolo[1,5-c]quinazoline

Conditions	Yield
In dimethyl sulfoxide at 110℃; for 24h; Mechanism; Solvent; Temperature; Time; Inert atmosphere; Schlenk technique; Sealed tube;	90%
In dimethyl sulfoxide at 110℃; for 24h; Schlenk technique; Inert atmosphere;	90%

Upstream product

• 79-24-3 Nitroethane 
• 1077-18-5 N-benzylidenebutan-1-amine 
• 100-52-7 benzaldehyde 
• 62753-13-3 (1-Nitro-allyl)-benzene 
• 25236-39-9 2-phenyl-1-nitroprop-1-ene 
• 100-46-9 benzylamine 
• 66618-80-2 1-phenyl-2-nitro-1-propanol acetate 
• 60593-26-2 (1-nitroethyl)-phosphonic acid diethyl ester 
• 58321-79-2 (Z)-(2-nitroprop-2-en-1-yl)benzene 
• 26251-08-1 2-nitro-1-phenylpropan-1-ol 
• 637-50-3 1-phenylpropene 
• 66618-80-2 acetic acid-((1RS,2RS)-2-nitro-1-phenyl-propyl ester) 
• 62634-68-8 Acetic acid 1-methyl-2-nitro-2-phenyl-ethyl ester 
• 90558-08-0 2,3-dinitro-3-phenyl propane 

Downstream Products

• 93159-92-3 (2-oxo-1-phenyl-propyl)-malonic acid diethyl ester 
• 546103-01-9 2-acetyl-4-nitro-3-phenyl-valeric acid ethyl ester 
• 102590-84-1 3-(2-nitro-1-phenyl-propyl)-2-phenyl-indole 
• 92851-01-9 (2-nitro-1-phenyl-propyl)-phenyl sulfide 
• 91473-95-9 5-<(Acetyl)(tert-butoxycarbonyl)methylenamino>-4,5-dihydro-2,5-dimethyl-4-phenyl-3-furancarbonsaeure-tert-butylester 
• 89730-46-1 2-Acetyl-4-aci-nitro-3-phenylpentansaeure-tert-butylester 
• 143647-41-0 diethyl (E)-4-nitro-3-phenyl-2-diethoxyphosphonyl-1-(4'-nitrophenyl)-1-pentene 
• 92851-01-9 syn-2-nitro-1-phenyl-1-(pphenylthio)propane 
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Relevant articles and documents

Active Base Hybrid Organosilica Materials based on Pyrrolidine Builder Units for Fine Chemicals Production

The catalytic activity of “pyrrolidine type” fragments included or anchored in the mesoporous silica supports or polymeric frameworks have been fully reported for enantioselective transformation. Nevertheless, low attention was focused on their catalytic abilities to perform base-catalyzed reaction. Accordingly, hybrid materials including pyrrolidine fragments in the mesoporous silica supports were prepared following different synthesis methods, such as micellar and fluoride sol-gel routes in absence of structural directing agents. Their great catalytic performance was explored for various base-catalyzed reactions to the formation of C?C bond through Knoevenagel, Claisen-Schmidt and Henry condensations under microwave irradiation. The benefits of microwave irradiation combined with suitable catalytic properties of pyrrolidine hybrid materials with strong base sites and high accessibility to active centers, allowed carrying out successfully base-catalyzed condensation reactions for the production of fine chemicals. Moreover, the hybrid catalyst exhibited high selectivity and good stability over different catalytic cycles contributing to environmental sustainability.

Dipolar HCP materials as alternatives to DMF solvent for azide-based synthesis

Hypercrosslinked polymers HCP-DMF and HCP-DMF-SO3H containing abundant and flexible DMF moieties were designed and synthesized. Benefitting from the solvation microenvironment provided by the pseudo-DMF moities, the polar HCPs manifested outstanding performances in the conversions of NaN3 to benzylic azides and 1,2,3-triazoles in EtOH (95%), respectively, avoiding the use of risky DMF and improving the separation processes of the products.

A diversity-oriented synthesis of polyheterocycles: Via the cyclocondensation of azomethine imine

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. The reaction involved azomethine imine formation and a cyclocondensation reaction as individual steps. The methodology provides excellent regio- and stereocontrol. Skeletal diversity was ensured by changing the electrophilic counterpart of azomethine imine. Due to its broader diversity and complexity, the DOS methodology is likely to benefit drug discovery and development in the future.