633283-53-1

Basic information

• Product Name: tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate
• Synonyms: tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate
• CAS NO: 633283-53-1
• Molecular Formula: C₁₄H₂₀ClN₃O₂
• Molecular Weight: 298
• Mol File: 633283-53-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate(633283-53-1)
• EPA Substance Registry System: tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate(633283-53-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 633283-53-1(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 4-(6-chloropyridin-3-yl)piperazine-1-carboxylate is a chemical compound with the molecular formula C16H24ClN3O2. It is a piperazine derivative that contains a tert-butyl group and a carboxylate ester group. The compound is used in organic synthesis and pharmaceutical research, particularly in the development of potential therapeutic agents. Its structure and functional groups make it a valuable intermediate for the synthesis of various biologically active compounds. However, it is important to handle this chemical with caution and adhere to safety protocols due to its potential hazards and reactivity.

Upstream product

• 53939-30-3 5-bromo-2-chloropyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1169698-64-9 C₃₀H₃₇N₇O₂ 
• 1374639-78-7 N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide 
• 1198408-35-3 6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 1588958-80-8 9-(3,3-dimethylcyclohexyl)-N-(5-(piperazin-1-yl)pyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine 
• 1588958-77-3 9-((1r,4r)-4-methylcyclohexyl)-N-(5-(piperazin-1-yl)pyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine 
• 1169692-54-9 9-(4-methylcyclohexyl)-N-(5-(1-piperazinyl)-2-pyridinyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine 
• 1169692-19-6 (9-cyclohexyl-9H-pyrido[4′,3′,4,5]pyrrolo[2,3-d]pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)amine 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3

We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays, led to the discovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound 28 inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb +) and U937 (FLT3WT) and induced cell death in MOLM13 (FLT3ITD) and even in MOLM13 (FLT3ITD, D835Y), which exhibits resistance to a number of FLT3 inhibitors currently under clinical development. At well-tolerated doses, compound 28 leads to significant growth inhibition of MOLM13 xenografts in nude mice, and the activity correlates with inhibition of STAT5 and Rb phosphorylation.

GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.