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1198408-35-3

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1198408-35-3 Usage

General Description

Tert-butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate is a synthetic chemical compound. It contains a tertiary butyl group and a piperidine ring, which is joined to a six-membered pyridine ring with an amino functional group at the 6-position. The carbonyl group of the piperidine ring is attached to an ester functional group, which in this case is a tert-butyl ester. This molecule is important because it can serve as a building block in synthetic organic chemistry, particularly in the creation of pharmaceuticals and other bioactive molecules. As this is a specialized chemical, it may seem to be important for lab research rather than any direct application.

Check Digit Verification of cas no

The CAS Registry Mumber 1198408-35-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,4,0 and 8 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1198408-35:
(9*1)+(8*1)+(7*9)+(6*8)+(5*4)+(4*0)+(3*8)+(2*3)+(1*5)=183
183 % 10 = 3
So 1198408-35-3 is a valid CAS Registry Number.

1198408-35-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 6-amino-3',4',5',6'-tetrahydro-2'H-3,4'-bipyridinyl-1'-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1198408-35-3 SDS

1198408-35-3Relevant articles and documents

Process method suitable for amplification preparation of 4-(6-aminopyridin-3-yl) substituted piperidine

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Paragraph 0040; 0041; 0044; 0045; 0046, (2019/12/25)

The invention discloses a process method suitable for amplification preparation of 4-(6-aminopyridin-3-yl) substituted piperidine, and belongs to the synthesis field of a medicine intermediate. N-substituted piperidone, aryl sulfohydrazide and 2-amino-5-bromopyridine are subjected to a coupling reaction under a palladium catalyst, and then are subjected to a hydrogenation to obtain 4-(6-aminopyridin-3-yl) substituted piperidine. According to the process, the raw materials in pyridine do not need to be protected; the condensation and the coupling are carried out in the same reaction kettle, sothat the operation cost is reduced, the steps of performing protection at first and then performing protection removal as in documents can be avoided, and production cost of the existing biological, medicine and chemical intermediates is greatly reduced; and the process is subjected to amplification verification in kilogram-scale, and the verification proves that the yield and the product purity are basically equal to those of gram-scale, so that the method can be used as a process for industrial scale production.

PYRIDINE CARBONYL DERIVATIVES AND THERAPEUTIC USES THEREOF AS TRPC6 INHIBITORS

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Page/Page column 50, (2019/05/15)

The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Streamlined Synthesis of Diaminopyridines by Pd-Catalyzed Ammonia Coupling with Deactivated Amino-Chloropyridines

Bourriquen, Florian,Bruneau-Voisine, Antoine,Jeandin, Aliénor,Stihle, Etienne,Fantasia, Serena

, p. 9006 - 9011 (2019/06/24)

An efficient and cost-effective two-step synthesis of diaminopyridines, fundamental building blocks of biologically active compounds, is reported. The advantages over previously reported routes include cost and wider availability of the bromo-chloropyridine starting materials and the straightforward accessibility to an extended array of diaminopyridine regioisomers. The key enabler of this synthetic strategy is the development of an unprecedented palladium-catalyzed coupling reaction of ammonia with chloropyridines deactivated by the presence of an alkylamino substituent. The coupling reaction was accomplished with very low catalyst loadings under remarkably mild reaction conditions, making the system particularly suitable for both academic and industrial applications. The utility of this methodology is exemplified by the application to the synthesis of highly relevant scaffolds, including the synthetic intermediates of the marketed drugs Ribociclib and Palbociclib.

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