633293-75-1

Upstream product

• 252342-51-1 (2S)-2-tert-butyldimethylsilyloxy-3-[(2S,3S,4S,5R)-4-tert-butyldimethylsilyloxy-3,5-dimethyl-6-oxotetrahydropyran-2-yl]propanal 
• 850211-69-7 tert-Butyl-[(Z)-(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octa-5,7-dienyloxy]-dimethyl-silane 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 850211-66-4 tert-Butyl-[(1R,2R,3S,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-1-((S)-1-methyl-2-trityloxy-ethyl)-hex-5-enyloxy]-dimethyl-silane 
• 850211-62-0 (S)-4-Benzyl-3-[(2S,3R,4S)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentanoyl]-oxazolidin-2-one 
• 850211-67-5 (2R,3R,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-7-trityloxy-heptanal 
• 850211-61-9 (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one 
• 850211-65-3 (3S,4S,5R,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-3,5,7-trimethyl-8-trityloxy-oct-1-en-4-ol 
• 398518-64-4 (2S,3R,4R,5S,6S,Z)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyldeca-7,9-dien-1-ol 
• 850211-63-1 (2R,3S,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentan-1-ol 
• 850211-64-2 (2S,3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentanal 

Relevant academic research and scientific papers

Total synthesis of (+)-discodermolide: A highly convergent fourth-generation approach

(Chemical Equation Presented) A highly convergent, fourth-generation total synthesis of (+)-discodermolide (1), with a longest linear sequence of 17 steps and an overall yield of 9.0%, has been achieved. Highlighting the strategy is the efficient construc

SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY DIENYL LACTONES AND MIMICS THEREOF

Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.