398518-64-4

Upstream product

• 1256166-31-0 (5R,6S)-5-((2R,3S,4S,Z)-3-(4-methoxybenzyloxy)-4-methylocta-5,7-dien-2-yl)-2,2,3,3,6,9,9,10,10-nonamethyl-4,8-dioxa-3,9-disilaundecane 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 850211-66-4 tert-Butyl-[(1R,2R,3S,4S)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-1-((S)-1-methyl-2-trityloxy-ethyl)-hex-5-enyloxy]-dimethyl-silane 
• 850211-62-0 (S)-4-Benzyl-3-[(2S,3R,4S)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentanoyl]-oxazolidin-2-one 
• 850211-67-5 (2R,3R,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-7-trityloxy-heptanal 
• 850211-61-9 (S)-4-Benzyl-3-((2S,3R,4S)-3-hydroxy-2,4-dimethyl-5-trityloxy-pentanoyl)-oxazolidin-2-one 
• 850211-65-3 (3S,4S,5R,6R,7S)-6-(tert-Butyl-dimethyl-silanyloxy)-3,5,7-trimethyl-8-trityloxy-oct-1-en-4-ol 
• 850211-63-1 (2R,3S,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentan-1-ol 
• 850211-64-2 (2S,3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-trityloxy-pentanal 

Downstream Products

• 633293-91-1 1-[(Z)-(1S,2R,3R,4S,8S,9R,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxymethoxy-2,4,6,8,10-pentamethyl-1-((Z)-(S)-1-methyl-penta-2,4-dienyl)-undec-6-enyloxymethyl]-4-methoxy-benzene 
• 852049-59-3 4-(tert-butyl-dimethyl-silanyloxy)-6-[12-(tert-butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyloxy)-2,6-bis-methoxymethoxy-5,7,9,11,13,15-hexamethyl-nonadeca-3,8,16,18-tetraenyl]-3,5-dimethyl-tetrahydro-pyran-2-one 
• 633293-75-1 Tetraene (+)-15 
• 870075-21-1 (5R,6S)-6-[(3Z,8Z)-(2S,5S,6S,7S,11S,12R,13R,14S,15S)-2,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyloxy)-6-methoxymethoxy-5,7,9,11,13,15-hexamethyl-nonadeca-3,8-dienyl]-5-methyl-tetrahydro-pyran-2-one 
• 870075-18-6 1-[(Z)-(1S,2R,3R,4S,8S,9R,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxymethoxy-2,4,6,8,10-pentamethyl-1-((S)-1-methyl-pentyl)-undec-6-enyloxymethyl]-4-methoxy-benzene 
• 870075-19-7 (Z)-(2S,3R,4S,8S,9R,10R,11S,12S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-3-methoxymethoxy-2,4,6,8,10,12-hexamethyl-hexadec-5-en-1-ol 
• 870074-98-9 tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane 
• 870075-17-5 (2S,3R,4R,5S,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4,6-trimethyl-decan-1-ol 
• 850211-69-7 tert-Butyl-[(Z)-(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octa-5,7-dienyloxy]-dimethyl-silane 

Relevant academic research and scientific papers

A practical approach to synthesize the C(9)-C(24) fragment of (+)-discodermolide

A practical and stereoselective synthesis of the C(9)-C(24) subunit of (+)-discodermolide has been achieved. The strategy featured the construction of the key intermediate Z-trisubstituted vinyl iodide 12 from the dibromoolefin 6 via an efficient modified

IMPROVED SYNTHESIS OF DISCODERMOLIDE AND VARIANTS THEREOF

Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).

Total synthesis of (+)-discodermolide: A highly convergent fourth-generation approach

(Chemical Equation Presented) A highly convergent, fourth-generation total synthesis of (+)-discodermolide (1), with a longest linear sequence of 17 steps and an overall yield of 9.0%, has been achieved. Highlighting the strategy is the efficient construc