633293-77-3

Upstream product

• 212703-47-4 2,4-dideoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-5-O-[(4-methoxyphenyl)-methyl]-2,4-dimethyl-L-arabinose 
• 607737-24-6 tert-Butyl-{(1R,2S)-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxy}-dimethyl-silane 

Downstream Products

• 633293-82-0 1-((2S,3R,4S)-3-Benzyloxymethoxy-2,4,6-trimethyl-hept-5-enyloxymethyl)-4-methoxy-benzene 
• 633293-80-8 (2-{(1R,2S)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyloxymethoxy}-ethyl)-trimethyl-silane 
• 633293-84-2 1-Methoxy-4-((2S,3R,4S)-3-methoxymethoxy-2,4,6-trimethyl-hept-5-enyloxymethyl)-benzene 
• 633293-78-4 Acetic acid (1R,2S)-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,4-dimethyl-pent-3-enyl ester 
• 633293-83-1 (2S,3R,4S)-3-Benzyloxymethoxy-2,4,6-trimethyl-hept-5-en-1-ol 

Relevant academic research and scientific papers

A Practical Improvement, Enhancing the Large-Scale Synthesis of (+)-Discodermolide: A Third-Generation Approach

(Equation presented) A significant improvement to the Penn one-gram synthesis of (+)-discodermolide (1) has been achieved. Specifically, reduction of the steric bulk of the C(11) hydroxyl protecting group permits formation of the requisite AB Wittig salt at the expense of the undesired intramolecular cyclization upon treatment with PPh3 at ambient pressure.