633310-95-9

Basic information

• Product Name: Piperidine, 1-[[1-[(2-amino-4-pyridinyl)methyl]-4-piperidinyl]carbonyl]-4-[3-(cyclohex ylmethyl)-5-fluoro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl]-
• CAS NO: 633310-95-9
• Molecular Formula: C31H41FN6O2
• Molecular Weight: 548.704
• Mol File: 633310-95-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[[1-[(2-amino-4-pyridinyl)methyl]-4-piperidinyl]carbonyl]-4-[3-(cyclohex ylmethyl)-5-fluoro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[[1-[(2-amino-4-pyridinyl)methyl]-4-piperidinyl]carbonyl]-4-[3-(cyclohex ylmethyl)-5-fluoro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl]-(633310-95-9)
• EPA Substance Registry System: Piperidine, 1-[[1-[(2-amino-4-pyridinyl)methyl]-4-piperidinyl]carbonyl]-4-[3-(cyclohex ylmethyl)-5-fluoro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl]-(633310-95-9)

Safety Data

• Hazardous Substances Data: 633310-95-9(Hazardous Substances Data)

Upstream product

• 107618-33-7 4-(5-fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester 
• 107618-21-3 4-(2-amino-4-fluoro-phenylamino)-piperidine-1-carboxylic acid ethyl ester 
• 1469924-45-5 C₂₂H₃₀FN₃O₃ 
• 1469924-58-0 C₁₉H₂₆FN₃O 
• 1469924-76-2 C₄₁H₅₇FN₆O₆ 

Relevant articles and documents

Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists

A novel series of benzimidazolone-containing histamine H 3-receptor antagonists were prepared and their structure-activity relationship was explored. These benzimidazolone analogs demonstrate potent H3-receptor binding affinities, no P450 enzyme inhibition, and strong H3 functional activity. Compound 1o exhibits the best overall profile with H3Ki = 0.95 nM and rat AUC = 12.9 μM h.