63334-86-1Relevant academic research and scientific papers
Inhibitors of NF-κB derived from thalidomide
Carcache de-Blanco, Esperanza J.,Pandit, Bulbul,Hu, Zhigen,Shi, Jiandong,Lewis, Andrew,Li, Pui-Kai
, p. 6031 - 6035 (2008/09/17)
A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-κB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-κB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
