63346-68-9Relevant academic research and scientific papers
Turn-on detection of targeted biochemical reactions by triple resonance NMR analysis using isotope-labeled probe
Mizusawa, Keigo,Igarashi, Ryuji,Uehira, Kosei,Takafuji, Yoshimasa,Tabata, Yasuhiko,Tochio, Hidehito,Shirakawa, Masahiro,Sando, Shinsuke,Aoyama, Yasuhiro
, p. 926 - 928 (2010)
We report on a strategy for the "turn-on" detection of target biochemical (metabolic) reactions using a triple resonance NMR technique with an isotope-labeled probe. Our NMR study clearly reveals that otherwise NMR-nonactive-l3C/2H-labeled glucose actually turns "on" its 1HNMR signal by conversion to an important biomarker lactate as the end product of anaerobic glycolysis in cells and in injected mice with high selectivity.
