6335-18-8

Basic information

• Product Name: 2-iodo-3,4-dimethoxybenzoic acid
• CAS NO: 6335-18-8
• Molecular Formula: C₉H₉IO₄
• Molecular Weight: 308.0698
• Mol File: 6335-18-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 370.2°C at 760 mmHg
• Flash Point: 177.7°C
• Density: 1.79g/cm³
• Vapor Pressure: 3.92E-06mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-iodo-3,4-dimethoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-3,4-dimethoxybenzoic acid(6335-18-8)
• EPA Substance Registry System: 2-iodo-3,4-dimethoxybenzoic acid(6335-18-8)

Safety Data

• Hazardous Substances Data: 6335-18-8(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 138490-94-5 2-iodoisovanillin 
• 93-07-2 Veratric acid 
• 138490-95-6 2-iodo-3,4-dimethoxybenzaldehyde 

Relevant articles and documents

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Competition of substituents for ortho direction of metalation of veratric acid

LTMP (5 equiv) metalates randomly veratric acid (1). Under external quench conditions, the thermodynamically more stable lithium 2-lithio-3,4-dimethoxybenzoate (2) reacts with a variety of electrophiles to give versatile building units that are not easily accessible by conventional means. Under in situ quench conditions (LTMP/TMSCl), a reversal of regioselectivity is observed and 6-trimethylsilyl-3,4-dimethoxybenzoic acid (10) is formed predominantly.