6336-02-3

Upstream product

• 50-00-0 formaldehyd 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 244139-11-5 2-diethoxymethyl-6-(3,4,5-trimethoxy-phenyl)-nicotinic acid ethyl ester 
• 1003869-38-2 C₃₂H₃₂N₂O₅ 
• 244139-05-7 2-diethoxymethyl-6-(3,4,5-trimethoxy-phenyl)-nicotinic acid methyl ester 

Relevant academic research and scientific papers

Design of two alternative routes for the synthesis of naftifine and analogues as potential antifungal agents

Two practical and efficient approaches have been implemented as alternative procedures for the synthesis of naftifine and novel diversely substituted analogues 16 and 20 in good to excellent yields, mediated by Mannich-type reactions as the key step of the processes. In these approaches, theγ-aminoalcohols 15 and 19 were obtained as the key intermediates and their subsequent dehydration catalyzed either by Br?nsted acids like H2SO4 and HCl or Lewis acid like AlCl3, respectively, led to naftifine, along with the target allylamines 16 and 20. The antifungal assay results showed that intermediates 18 (bearing both a β-aminoketo- and N-methyl functionalities in their structures) and products 20 were the most active. Particularly, structures 18b, 18c, and the allylamine 20c showed the lowest MIC values, in the 0.5-7.8 μg/mL range, against the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. Interesting enough, compound 18b bearing a 4-Br as the substituent of the phenyl ring, also displayed high activity against Candida albicans and Cryptococcus neoformans with MIC80 = 7.8 μg/mL, being fungicide rather than fungistatic with a relevant MFC value = 15.6 μg/mL against C. neoformans.

Development, Synthesis, and Biological Evaluation of (-)-trans-(2S,5S)-2--4-n-propoxy-5-(3-hydroxypropoxy)-phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a Potent Orally Active Platelet-Activating Factor (PAF) Antagonist and

(-)-trans-(2S,5S)-2--4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (10) is one of the most potent platelet-activating factor (PAF) antagonists in vitro and in vivo developed to date.This diaryl

CERTAIN 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) STR1 wherein R 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group and R 6 is an alkoxy or a substituted alkoxy or alkyl group.

2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) STR1 wherein R4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R6 is an alkyl or a substituted alkyl group and the substituents at positions 3, 4 or 5 are acyclic.