6336-16-9

Upstream product

• 100-51-6 benzyl alcohol 
• 28697-53-2 D-arabinopyranose 
• 67-64-1 acetone 
• 5329-50-0 (-)-benzyl β-D-arabinopyranoside 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 109454-66-2 benzyl-(O²-acetyl-O³,O⁴-isopropyliden-β-D-arabinopyranoside) 
• 116667-61-9 benzyl-{O²-benzoyl-O³,O⁴-isopropyliden-β-D-arabinopyranoside} 
• 7143-64-8 (-)-benzyl 2-O-methanesulfonyl-β-D-arabinopyranoside 
• 84035-77-8 3,4-O-Isopropyliden-D-arabinose 
• 129840-46-6 1,2-di-O-benzyl-3,4-O-isopropylidene-β-D-arabinopyranoside 
• 75336-68-4 (2S,3S,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-((3aR,6R,7S,7aR)-6-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 75935-18-1 Benzyl-2-O-tert-butyldimethylsilyl-3,4-O-isopropyliden-β-D-arabinopyranosid 
• 120041-96-5 benzyl 3,4-O-isopropylidene-2-O-methanesulfonyl-β-D-arabinopyranoside 
• 123551-38-2 (3aR,6R,7aS)-6-Benzyloxy-2,2-dimethyl-7-methylene-tetrahydro-[1,3]dioxolo[4,5-c]pyran 
• 273931-33-2 ((3aR,6R,7R,7aS)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methanol 
• 273931-35-4 ((3aR,6R,7R,7aS)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ylmethoxy)-tert-butyl-dimethyl-silane 
• 114218-06-3 benzyl 2-deoxy-2,2'-dideuterio-β-D-ribopyranoside 
• 114218-05-2 benzyl 3,4-isopropylidene-2-deoxy-2,2'-dideuterio-erythro-pentopyranoside 
• 114218-04-1 benzyl 3,4-isopropylidene-2(R)-deuterio-β-D-erythro-pentopyranoside 

Relevant academic research and scientific papers

A Click-Chemistry Linked 2′3′-cGAMP Analogue

2′3′-cGAMP is an uncanonical cyclic dinucleotide where one A and one G base are connected via a 3′-5′ and a unique 2′-5′ linkage. The molecule is produced by the cyclase cGAS in response to cytosolic DNA binding. cGAMP activates STING and hence one of the most powerful pathways of innate immunity. cGAMP analogues with uncharged linkages that feature better cellular penetrability are currently highly desired. Here, the synthesis of a cGAMP analogue with one amide and one triazole linkage is reported. The molecule is best prepared via a first CuI-catalyzed click reaction, which establishes the triazole, while the cyclization is achieved by macrolactamization.

Stereochemistry of enacyloxins. Part 6: Synthesis of C16′-C23′ fragments of enacyloxins, a series of antibiotics from Frateuria sp. W-315

The C16′-C23′ fragments of enacyloxins, a series of antibiotics isolated from Frateuria sp. W-315, were synthesized from D-arabinose. Copyright by Walter de Gruyter Berlin Boston.

NEW METHOD FOR PREPARING ISOFAGOMINE AND ITS DERIVATIVES

A method for preparing isofagomine, its derivatives, intermediates and salts thereof using novel processes to make isofagomine from D-(-)-arabinose and L-(-)-xylose.

Tartrate sale of isofagomine and methods of use

A novel tartaric acid salt of Isafagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.

A convergent total synthesis of hemibrevetoxin B

A convergent biomimetic synthesis of hemibrevetoxin B from d-glucal and d-arabinose utilizes an electrophile-promoted cascade anti-Baldwin cyclization of an epoxy alcohol. The epoxy alcohol arises from a palladium-catalyzed coupling of a highly functionalized organozinc compound and an alkenyl iodide, which serve as two chiral building blocks of similar size and complexity. This first successful implementation of a cascade epoxy alcohol cyclization for the synthesis of marine polycyclic ether toxins proceeds in 39 steps and 4% overall yield. Copyright

Synthesis of a diazasugar with nitrogen in place of the anomeric carbon and glycosidic oxygen

A D-galactose analogue with a hydrazine in place of C-1 was synthesised.

REGIOSPECIFIC SYNTHESIS OF 2'-DEOXY-2',2''-DIDEUTERIO NUCLEOSIDES

Two routes have been devised for the first synthesis of 2',2''-dideuterio-2'-deoxynucleosides.First route involves the oxidation of an appropriately 3',5'-protected ribonucleosides with CrO3-pyridine-acetic anhydride complex, followed by direct