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1,4-bis[(4-fluorophenyl)sulfonyl]piperazine is a complex organic compound with the molecular formula C18H16F2N2O4S2. It is characterized by a central piperazine ring, which is a heterocyclic amine containing two nitrogen atoms, and two 4-fluorophenylsulfonyl groups attached to the 1 and 4 positions of the piperazine. The 4-fluorophenylsulfonyl groups consist of a benzene ring with a fluorine atom at the 4-position and a sulfonyl group (-SO2-) attached to it. 1,4-bis[(4-fluorophenyl)sulfonyl]piperazine is known for its potential applications in the synthesis of pharmaceuticals and as a chemical intermediate due to its unique structure and reactivity. It is typically synthesized through a series of chemical reactions involving the piperazine core and the introduction of the sulfonyl groups. The compound's properties, such as its solubility and stability, can be influenced by the presence of the fluorine atoms and the sulfonyl groups, making it a subject of interest in organic chemistry and medicinal chemistry research.

6337-96-8

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6337-96-8 Usage

Chemical structure

Piperazine derivative with two sulfonyl groups and two 4-fluorophenyl groups attached to the piperazine ring

Application

Commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds

Field of study

Medicinal chemistry

Potential use

Development of new therapeutic agents

Stability

High stability

Reactivity

High reactivity

Intermediate

Useful intermediate for the preparation of various bioactive molecules

Check Digit Verification of cas no

The CAS Registry Mumber 6337-96-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,3 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6337-96:
(6*6)+(5*3)+(4*3)+(3*7)+(2*9)+(1*6)=108
108 % 10 = 8
So 6337-96-8 is a valid CAS Registry Number.

6337-96-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-bis[(4-fluorophenyl)sulfonyl]piperazine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6337-96-8 SDS

6337-96-8Downstream Products

6337-96-8Relevant academic research and scientific papers

Synthesis, biological evaluation, and qpld studies of piperazine derivatives as potential dpp-iv inhibitors

Al-Qirim, Tariq,Jarad, Haya Abu,Khalaf, Reema Abu,Sabbah, Dima

, p. 937 - 944 (2021/11/30)

Background: Diabetes mellitus is a serious global health issue, currently affecting 425 million people and is set to affect over 690 million people by 2045. It is a chronic disease characterized by hyperglycemia due to relative or absolute insulin hormone deficiency. Dipeptidyl peptidaseIV (DPP-IV) inhibitors are hypoglycemic agents augmenting the action of the incretin hormones that stimulate insulin secretion from the pancreatic beta cells. Objective: In this study, synthesis and biological evaluation of seven piperazine derivatives 3a-g was carried out. Methods: The synthesized molecules were characterized using proton-nuclear magnetic resonance, carbon-nuclear magnetic resonance, infrared spectroscopy and mass spectrometry. Results: In vitro biological evaluation study showed comparable DPP-IV inhibitory activity for the targeted compounds ranging from 19%-30% at 100 μM concentration. Furthermore, the in vivo hypoglycemic activity of 3d was evaluated using streptozotocin-induced diabetic mice. It was found that compound 3d significantly decreased the blood glucose level when the diabetic group treated with 3d was compared to the control diabetic group. Quantum–Polarized Ligand Docking (QPLD) studies demonstrate that 3a-g fit the binding site of DPP-IV enzyme and form H-bonding with the backbones of R125, E205, E206, K554, W629, Y631, Y662, R669, and Y752. Conclusion: Piperazine derivatives were successfully found to be new scaffolds as potential DPP-IV inhibitors.

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