63378-99-4

Upstream product

• 75-55-8 2-Methylaziridine 
• 99-33-2 3,5-dinitrobenoyl chloride 
• 99-34-3 3,5-dinitrobenzoic acid 
• 87581-19-9 2,5-dioxopyrrolidin-1-yl 3,5-dinitrobenzoate 

Downstream Products

• 1335200-09-3 C₁₀H₉N₃O₅ 
• 1335199-99-9 2-(3,5-dinitrophenyl)-4-methyl-4,5-dihydrooxazole 
• 1407164-55-9 (R)-(3,5-dinitrophenyl)(2-methylaziridin-1-yl)methanone 

Relevant academic research and scientific papers

Scalable synthesis of N -acylaziridines from N -tosylaziridines

N-Acylaziridines are important starting materials for the synthesis of chiral amine derivatives. The traditional methods for producing these activated aziridines have significant drawbacks. The gram scale synthesis of N-acylaziridines by deprotection of N

Enantioselective synthesis and stereoselective ring opening of N-acylaziridines

Kinetic resolution of N-acylaziridines by nucleophilic ring opening was achieved with (R)-BINOL as the chiral modifier under boron-catalyzed conditions (see scheme; Ar=3,5-dinitrophenyl). The consumed enantiomer of aziridine can be further converted to an enantioenriched 1,2-chloroamide with recovery of (R)-BINOL. Copyright

Phosphine-catalyzed heine reaction

Aziridines are important synthetic intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The reactions o