75-55-8

Hazards Identification

Pictogram(s):

Signal:

Danger

GHS Hazard Statements:

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]
H300: Fatal if swallowed [Danger Acute toxicity, oral]
H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
H330: Fatal if inhaled [Danger Acute toxicity, inhalation]
H350: May cause cancer [Danger Carcinogenicity]
H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes:

P203, P210, P233, P240, P241, P242, P243, P260, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P320, P321, P330, P361+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories:

Flam. Liq. 2
Carc. 1B
Acute Tox. 1
Acute Tox. 2 *
Eye Dam. 1
Aquatic Chronic 2
Flammable liquid - category 2
Acute toxicity (ingestion) - category 2
Acute toxicity (dermal) - category 1
Acute toxicity (inhalation) - category 1
Carcinogenicity - category 1B
Germ cell mutagenicity - category 1B
Skin corrosion - category 1C
Hazardous to the aquatic environment (chronic) - category 2
Flammable liquids - Category 2
Acute toxicity (Oral) - Category 2
Acute toxicity (Dermal) - Category 2
Acute toxicity (Inhalation: Vapours) - Category 2
Skin corrosion/irritation - Category 2
Serious eye damage/eye irritation - Category 2A
Carcinogenicity - Category 2
Specific target organ toxicity - Single exposure - Category 3 (Respiratory tract irritation)
Carcinogens, Flammable - 3rd degree

Hazards Summary:

1,2-Propyleneimine is used as an intermediate in the paper, textile, rubber, and pharmaceutical industries. 1,2-Propyleneimine is severely irritating to the eyes and upper respiratory tract from acute (short-term) inhalation exposure in humans. Headaches, dizziness, nausea, bronchitis, shortness of breath, and edema of the lungs have also been reported in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of 1,2-propyleneimine in humans. Animal studies have reported effects on the kidneys, blood, and gastrointestinal system from chronic inhalation and oral exposure to 1,2-propyleneimine. Animal studies have reported tumors of the mammary glands and intestines, leukemia, and other tumor types from oral exposure to 1,2-propyleneimine. The International Agency for Research on Cancer (IARC) has classified 1,2-propyleneimine as a Group 2B, possible human carcinogen. EPA has not classified 1,2-propyleneimine for carcinogenicity.

Usage

Uses

Used in Chemical Industry:
2-Methylaziridine is used as an intermediate for the production of polymers, coatings, adhesives, textiles, and paper finishes. It serves as a crucial component in the synthesis of various chemical products due to its reactive nature and ability to form a wide range of compounds.
Used in Pharmaceutical Industry:
2-Methylaziridine is used as a renal papillary toxin, which can have potential applications in the development of drugs targeting specific renal conditions. Its unique chemical structure allows it to interact with specific biological targets, making it a valuable compound for pharmaceutical research and development.

Air & Water Reactions

Highly flammable. Soluble in water. Reacts slowly and non hazardously with water to form propanolamine or methylethanolamine.

Reactivity Profile

PROPYLENEIMINE, [INHIBITED] is subject to violent polymerization on contact with an acid. (The inhibitor is intended to prevent polymerization). Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, dangerous fire risk. Toxic by ingestion, inhalation, and skin absorption. Upper respiratory tract irritant and kidney damage. Possi- ble carcinogen.

Health Hazard

Toxic after acute exposure. Can severely irritate eyes, skin, and lungs.

Fire Hazard

Chemical is extremely flammable; vapors are heavier than air. Toxic oxides of nitrogen are produced during combustion. Avoid acids, strong oxidizers. Thermally unstable. Hazardous polymerization may occur. Contact with acid promotes violent polymerization.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion and skin contact. Moderately toxic by inhalation. Mutation data reported. Severe eye irritant. Implicated as a brain carcinogen. A flammable liquid and very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Polymerizes explosively on exposure to acids or acid fumes. A storage hazard. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Propyleneimine is used in the modifi- cation of latex surface coating resins; in the production of polymers for use in the paper and textile industries as coat- ings and adhesives.

Carcinogenicity

2-Methylaziridine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN1921 Propyleneimine, stabilized, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous materials.

Incompatibilities

Vapors or liquid form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water, carbonyl compounds; quinones, sulfonyl halides. May explode in heat. Subject to violent polymerization in contact with acids. Hydrolyzes in water to form methylethanolamine.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

InChI:InChI=1/C3H5N/c1-2-3-4/h2,4H,1H3

Upstream product

• 926-25-0 2-amino-1-methlethyl hydrogen sulfate 
• 1908-84-5 (+/-)-sulfuric acid mono-(2-amino-propyl ester) 
• 37143-56-9 2-amino-1-chloropropane 
• 78-96-6 3-amino-2-propanol 
• 14753-25-4 2-chloropropylamine 
• 156-87-6 propan-1-ol-3-amine 
• 75-55-8 2-Methylaziridine 

Downstream Products

• 39657-33-5 2-methyl-1-phenethyl-aziridine 
• 123620-68-8 1-acetyl-2-methyl-aziridine 
• 13009-91-1 tris-(2-methyl-aziridin-1-yl)-[1,3,5]triazine 
• 10212-58-5 2-methyl-aziridine-1-carboxylic acid octadecylamide 
• 100121-85-5 2,6-dibromo-3,5-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 69973-30-4 2,5-bis-acetylamino-3,6-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 100398-38-7 3-chloro-4-(2-methyl-aziridin-1-yl)-[1,2]naphthoquinone 
• 16058-49-4 2,5-bis(2-methylaziridinyl)-1,4-benzoquinone 
• 18673-68-2 dibenzyl-bis-(2-methyl-aziridin-1-yl)-silane 
• 110059-24-0 2,5-bis-(2-methyl-aziridin-1-yl)-3,6-bis-propionylamino-[1,4]benzoquinone 
• 21384-07-6 2,5-dichloro-3,6-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 98998-27-7 2-methyl-aziridine-1-carboxylic acid diethylamide 
• 21384-06-5 2,5-bis-(2-methyl-aziridin-1-yl)-hydroquinone 
• 3901-51-7 N,N'-bis-(2-methyl-aziridine-1-carbonyl)-hexanediyldiamine 

Relevant academic research and scientific papers

Synthetic method of aromatic aziridine cross-linking agent

The invention discloses a synthetic method of an aromatic aziridine cross-linking agent (figure 1). The method comprises three chemical synthesis steps: (I) reacting 1-amino-2-propanol with chlorosulfonic acid to obtain amino-isopropyl sulfate; (II) carrying out an intra-molecular nucleophilic substitution reaction on amino-isopropyl sulfate in alkali liquor, removing sulfate radical groups, and carrying out ring closing to generate an intermediate 2-methyl aziridine; and (III) directly reacting the obtained 2-methyl aziridine with isophthaloyl dichloride in a mixed system of alkali liquor andan organic solvent without separation, and carrying out separation and purification to obtain a final product 1,1'-(1,3-phthaloyl)bis(2-methyl-aziridine). The commodity name is HX-752, and the aromatic aziridine cross-linking agent has wide application. A liquid-liquid homogeneous or heterogeneous reaction is adopted, the reaction conditions are mild, the process is simple and easy to control, and the yield is high. Besides, the synthesis method has the advantages of fewer byproducts and low waste discharge amount, is suitable for large-scale production, and has favorable industrialization prospects.

Preparation method of 2-methylaziridine

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of 2-methylaziridine. The 2-methylaziridine is synthesized from isopropanolamine, sulfuric acid and liquid caustic soda as raw materials, the synthesis condition is mild, and mass industrial production is facilitated. Besides, the synthesis materials are simple, sulfate esterification and liquid caustic soda hydrolysis are adopted, caustic soda flakes are used for purification in the distillation and purification process, few byproducts are produced, and the method is green and environmentally friendly; initial distillation under normal pressure and fine distillation under low pressure are adopted, and the obtained 2-methylaziridine has the purity of 99% or above.

CATALYST FOR SYNTHESIZING ETHYLENIMINE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst comprises a carrier and metal ions loaded on the carrier; the carrier is a composite oxide comprising titanium, silicon and phosphorus elements; the metal ions are magnesium ions, iron ions and cesium ions; the molar ratio of the magnesium ions to the iron ions to the cesium ions is (1-10):1:0.1; the mass of all metal ions is 0.5-10 percent of that of the carrier. In the related preparation method, a catalyst precursor is roasted at the temperature of 350-650° C., so that the catalyst is obtained; the catalyst precursor is the mixture of the carrier, soluble salt of magnesium, soluble salt of iron and soluble salt of cesium. The present invention also provides the application of the catalyst to synthesis of the ethylenimine by using amino alcohol as the raw material. Compared with a common catalyst which has the requirement on the temperature of over 400° C., the catalyst of the present invention obviously reduces the reaction temperature. The prepared catalyst can catalyze the intramolecular dehydration reaction of the amino alcohol and has relatively excellent selectivity.

An improved and mild wenker synthesis of aziridines

The conventional Wenker synthesis of aziridines from vicinal amino alcohols has been modified by employing mild reaction conditions. Amino alcohols were converted into their hydrogen sulfates with chlorosulfonic acid. The sulfates were cyclized with sodium hydroxide, and even with non-nucleophilic sodium carbonate. The current, improved method extends the scope of the typical Wenker synthesis and is applicable to unstable amino alcohols in hot sulfuric acid and to unstable sulfates which favor elimination and hydroxide displacement in the presence of strong base. Georg Thieme Verlag Stuttgart.

Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides

This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

Efficient Optical Resolution of Aziridines with Optically active host compounds

Some aziridines are resolved efficiently by complexation with optically active host compounds which were derived from tartaric acid.

Aziridino containing nitro imidazoles and pharmaceutical compositions

A compound of formula I STR1 in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1.

CATALYTIC SYNTHESIS OF DIAZINES FROM 1,3-DIAMINOPROPANE AND 3-AMINO-1-PROPANOL

The transformation of 1,3-diaminopropane and 3-amino-1-propanol under pulse conditions over tungsten trioxide in an inert atmosphere at 300-500 deg C were investigated.The transformation of 1,3-diaminopropane leads to the formation of saturated pyrimidine