75-55-8

Basic information

• Product Name: 2-Methylaziridine
• Synonyms: (R,S)-2-Methyl-aziridine;1,2-Propyleneimine;1,2-Propylenimine;1,2-propylenimine(2-methylaziridine);2-Methylazacyclopropane;2-methyl-aziridin;2-Methylethylenimine;ai3-50325
• CAS NO: 75-55-8
• Molecular Formula: C₃H₇N
• Molecular Weight: 57.09
• EINECS: 200-878-7
• Product Categories: Amines;Heterocycles;Aziridines;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 75-55-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: -65°C
• Boiling Point: 66°C
• Flash Point: -4°C
• Appearance: colorless liquid
• Density: 0.8
• Vapor Pressure: 736.845mmHg at 25°C
• Refractive Index: 1.4125
• Storage Temp.: 2-8°C
• PKA: pK1:8.18(+1) (25°C)
• Water Solubility: miscible
• Stability: Unstable - readily polymerises in the absence of an inhibitor. May polymerize vigorously or explosively in the presence of acids
• CAS DataBase Reference: 2-Methylaziridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylaziridine(75-55-8)
• EPA Substance Registry System: 2-Methylaziridine(75-55-8)

Safety Data

• Hazard Codes: F;T+;N,T,F,N,T+,Xn
• Statements: 45-11-26/27/28-41-51/53-35-48/20/22-40-36/38-20/22-63-48/22-38-22
• Safety Statements: 53-45-61-36/37/39-28-26-36/37
• RIDADR: 1921
• RTECS: CM8050000
• HazardClass: 3.1
• PackingGroup: I
• Hazardous Substances Data: 75-55-8(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 75-55-8 differently. You can refer to the following data:
1. colourless oily fuming liquid
2. Propyleneimine is a fuming, colorless, oily liquid with a strong ammonia-like odor.

Uses

Different sources of media describe the Uses of 75-55-8 differently. You can refer to the following data:
1. The renal papillary toxin.
2. Intermediate in production of polymers, coatings, adhesives, textiles, and paper finishes.

General Description

A clear colorless liquid with an ammonia-like odor. Flash point 25°F. Toxic by ingestion, inhalation and through skin absorption. Less dense than water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Under prolonged exposure to fire or heat the containers may rupture violently and rocket. Used as an organic intermediate.

Air & Water Reactions

Highly flammable. Soluble in water. Reacts slowly and non hazardously with water to form propanolamine or methylethanolamine.

Reactivity Profile

PROPYLENEIMINE, [INHIBITED] is subject to violent polymerization on contact with an acid. (The inhibitor is intended to prevent polymerization). Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, dangerous fire risk. Toxic by ingestion, inhalation, and skin absorption. Upper respiratory tract irritant and kidney damage. Possi- ble carcinogen.

Health Hazard

Toxic after acute exposure. Can severely irritate eyes, skin, and lungs.

Fire Hazard

Chemical is extremely flammable; vapors are heavier than air. Toxic oxides of nitrogen are produced during combustion. Avoid acids, strong oxidizers. Thermally unstable. Hazardous polymerization may occur. Contact with acid promotes violent polymerization.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion and skin contact. Moderately toxic by inhalation. Mutation data reported. Severe eye irritant. Implicated as a brain carcinogen. A flammable liquid and very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Polymerizes explosively on exposure to acids or acid fumes. A storage hazard. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Propyleneimine is used in the modifi- cation of latex surface coating resins; in the production of polymers for use in the paper and textile industries as coat- ings and adhesives.

Carcinogenicity

2-Methylaziridine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN1921 Propyleneimine, stabilized, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous materials.

Incompatibilities

Vapors or liquid form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water, carbonyl compounds; quinones, sulfonyl halides. May explode in heat. Subject to violent polymerization in contact with acids. Hydrolyzes in water to form methylethanolamine.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

InChI:InChI=1/C3H5N/c1-2-3-4/h2,4H,1H3

Upstream product

• 926-25-0 2-amino-1-methlethyl hydrogen sulfate 
• 1908-84-5 (+/-)-sulfuric acid mono-(2-amino-propyl ester) 
• 78-96-6 3-amino-2-propanol 
• 14753-25-4 2-chloropropylamine 
• 156-87-6 propan-1-ol-3-amine 
• 75-55-8 2-Methylaziridine 
• 37143-56-9 2-amino-1-chloropropane 

Downstream Products

• 39657-33-5 2-methyl-1-phenethyl-aziridine 
• 123620-68-8 1-acetyl-2-methyl-aziridine 
• 13009-91-1 tris-(2-methyl-aziridin-1-yl)-[1,3,5]triazine 
• 10212-58-5 2-methyl-aziridine-1-carboxylic acid octadecylamide 
• 100121-85-5 2,6-dibromo-3,5-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 69973-30-4 2,5-bis-acetylamino-3,6-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 100398-38-7 3-chloro-4-(2-methyl-aziridin-1-yl)-[1,2]naphthoquinone 
• 16058-49-4 2,5-bis(2-methylaziridinyl)-1,4-benzoquinone 
• 18673-68-2 dibenzyl-bis-(2-methyl-aziridin-1-yl)-silane 
• 110059-24-0 2,5-bis-(2-methyl-aziridin-1-yl)-3,6-bis-propionylamino-[1,4]benzoquinone 
• 21384-07-6 2,5-dichloro-3,6-bis-(2-methyl-aziridin-1-yl)-[1,4]benzoquinone 
• 98998-27-7 2-methyl-aziridine-1-carboxylic acid diethylamide 
• 21384-06-5 2,5-bis-(2-methyl-aziridin-1-yl)-hydroquinone 
• 3901-51-7 N,N'-bis-(2-methyl-aziridine-1-carbonyl)-hexanediyldiamine 

Relevant articles and documents

Synthetic method of aromatic aziridine cross-linking agent

The invention discloses a synthetic method of an aromatic aziridine cross-linking agent (figure 1). The method comprises three chemical synthesis steps: (I) reacting 1-amino-2-propanol with chlorosulfonic acid to obtain amino-isopropyl sulfate; (II) carrying out an intra-molecular nucleophilic substitution reaction on amino-isopropyl sulfate in alkali liquor, removing sulfate radical groups, and carrying out ring closing to generate an intermediate 2-methyl aziridine; and (III) directly reacting the obtained 2-methyl aziridine with isophthaloyl dichloride in a mixed system of alkali liquor andan organic solvent without separation, and carrying out separation and purification to obtain a final product 1,1'-(1,3-phthaloyl)bis(2-methyl-aziridine). The commodity name is HX-752, and the aromatic aziridine cross-linking agent has wide application. A liquid-liquid homogeneous or heterogeneous reaction is adopted, the reaction conditions are mild, the process is simple and easy to control, and the yield is high. Besides, the synthesis method has the advantages of fewer byproducts and low waste discharge amount, is suitable for large-scale production, and has favorable industrialization prospects.

CATALYST FOR SYNTHESIZING ETHYLENIMINE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst comprises a carrier and metal ions loaded on the carrier; the carrier is a composite oxide comprising titanium, silicon and phosphorus elements; the metal ions are magnesium ions, iron ions and cesium ions; the molar ratio of the magnesium ions to the iron ions to the cesium ions is (1-10):1:0.1; the mass of all metal ions is 0.5-10 percent of that of the carrier. In the related preparation method, a catalyst precursor is roasted at the temperature of 350-650° C., so that the catalyst is obtained; the catalyst precursor is the mixture of the carrier, soluble salt of magnesium, soluble salt of iron and soluble salt of cesium. The present invention also provides the application of the catalyst to synthesis of the ethylenimine by using amino alcohol as the raw material. Compared with a common catalyst which has the requirement on the temperature of over 400° C., the catalyst of the present invention obviously reduces the reaction temperature. The prepared catalyst can catalyze the intramolecular dehydration reaction of the amino alcohol and has relatively excellent selectivity.

Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides

This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.